Background: Coriandrum sativum L. has been recommended for relief of insomnia in Iranian traditional medicine. However, no pharmacological studies have yet evaluated its sedative effects. The aim of this study was to determine if extracts and essential oil of coriander seeds have sedative-hypnotic activity. Methods: The aqueous or hydro-alcoholic extracts or essential oil of coriander seeds (10...

This article examines how Palestinians' intergroup contact experiences relate to their attitudes towards interactions with Israelis (i.e., normalization). We draw on four recent advances in literature. First, research indicates that positive can impede disadvantaged groups' motivation challenge inequalities. Second, increased endorsement of normalization mediates this sedative effect resist the...

Insomnia and anxiety are worldwide medical problems. Plant extracts possessed sedative anxiolytic effect via different mechanisms included interactions with Na+ channels, γ-aminobutyric acid type A receptors, N-methyl-D-aspartate receptors chatecholamines. In the current review, Web Science, PubMed, Scopus Science Direct, were searched to investigate plants effects

The present study investigated the sedative effects of Sophora flavescens (SF) and its bioactive compound, matrine through performing locomotor activity test and the electroencephalography (EEG) analysis in the rat. The underlying neural mechanism of their beneficial effects was determined by assessing c-Fos immunoreactivity and serotonin (5-HT) in the brain utilizing immunohistochemical method...

945 November 2012 I N this issue of ANESTHESIOLOGY, Hu et al.1 delve into the mechanisms of hypnotic action of potent volatile anesthetic agents as well as dexmedetomidine; these data build upon previous work from this and other laboratories that collectively provide insights that may affect how these agents are used in clinical practice.2–8 Using mice that lack the dopamine-βhydroxylase (DβH) ...

Since the first report of clonidine, an alpha2-adrenoceptor agonist, the indications for this class of drugs have continued to expand. In December 1999, dexmedetomidine was approved as the most recent agent in this group and was introduced into clinical practice as a short-term sedative (<24 hours). Alpha2-adrenoceptor agonists have several beneficial actions during the perioperative period. Th...

Of the various agents which have been employed for sedation in patients undergoing electrocardioversion, diazepam has had the most extensive use. However, this agent possesses several disadvantages including pain and venous complications at the site of injection and a lower incidence of amnesia. Midazolam, a benzodiazepine derivative, is being increasingly used in general and local anesthesia a...

Remimazolam (CNS 7056) is a new drug innovation in anesthesia. It combines the properties of two unique drugs already established in anesthesia - Midazolam and remifentanil. It acts on GABA receptors like midazolam and has organ-independent metabolism like remifentanil. It is likely to be the sedative of the future, as preliminary phase II trials have shown minimal residual effects on prolonged...