OBJECTIVE Our previous research has concerned the role of macrophages in joint inflammation in rheumatoid arthritis. We have therefore been interested in liposomes containing clodronate as an antimacrophage treatment for arthritis. We have used the antigen-induced arthritis model in sheep to evaluate the effect of clodronate liposomes. METHODS Arthritis was induced in the right hock joint (da...

Synovial joints are generally considered to consist of a number of discrete elements (capsule, cartilaginous articular surfaces, synovial fluid, and synovium'); and synovial fluid is regarded as a body fluid lying within a tissue space bounded by synovium. Because this arrangement is reminiscent of the major body cavities, synovium and synovial fluid are often discussed in similar terms to thos...

This paper describes a new toolkit SCARF for doing speech recognition with segmental conditional random fields. It is designed to allow for the integration of numerous, possibly redundant segment level acoustic features, along with a complete language model, in a coherent speech recognition framework. SCARF performs a segmental analysis, where each segment corresponds to a word, thus allowing f...

BACKGROUND To determine the effects of liposomal targeting of prednisolone phosphate (Lip-PLP) to synovial lining macrophages on M1 and M2 polarization in vitro and during experimental arthritis. MATERIAL AND METHODS Experimental arthritis (antigen and immune complex induced) was elicited in mice and prednisolone containing liposomes were given systemically. Synovium was investigated using mi...

1. Abstract A 2-dimensional lumbar spine is modeled with 64 back muscles and the static behavior of the model is predicted using an optimization technique. The goal of this study was to investigate if a follower load can be produced by the back muscles for enhancing the mechanical stability of the lumbar spine in a quiet standing posture. Recent studies demonstrated that the stability of the lu...

Rheumatoid arthritis is an autoimmune disease that causes joint damage due to inflammation in the soft tissue lining joints known as synovium. It vital identify soon possible provide necessary treatment early and prevent further bone structures. Radiographs are often used assess extent of damage. Currently, scoring from radiograph takes expertise, effort, time. Joint associated with rheumatoid ...