Epilepsy is defined as the tendency for recurrent seizures to occur without acute provocation. Every child’s (and adult’s) brain is capable of generating a seizure with certain pro-convulsive drugs and it should therefore be of no surprise that seizures may be provoked by numerous other factors including: an acute metabolic (biochemical) disturbance, central nervous infection, drug intoxication...

OBJECTIVE There is a complex bidirectional relationship between sleep and epilepsy. Sleep/wake timing of seizures has been investigated for several individual seizure types and syndromes, but few large-scale studies of the timing of seizures exist in people with varied epilepsy types. In addition, the genetic contributions to seizure timing have not been well studied. METHODS Sleep/wake timin...

OBJECTIVE To determine the incidence, risk factors and outcomes of early post-craniotomy seizures. METHODS This was a retrospective cohort study of all patients who underwent craniotomy for primary brain tumor resection (2002-2011) and admitted postoperatively to the intensive care unit. The patients were divided into 2 groups depending on the occurrence of seizures within 7 days. RESULTS O...

Repeated kindled seizures induce long-lasting physiological and morphological alterations in the hippocampal formation. In the dentate gyrus (DG), the morphological alterations induced by kindled seizures include loss of polymorphic neurons in the hilus, mossy fiber axon sprouting, and synaptic reorganization of the mossy fiber pathway. In this study, quantitative stereological methods were use...

Background: Seizures in childhood absence epilepsy (CAE) are typically easily controlled with anti-seizure medications (ASMs). Factors predictive of treatment resistance remain unclear. Our objectives were to assess prevalence neuropsychiatric problems and factors influencing a cohort CAE at single centre. Methods: We retrospectively reviewed patients diagnosed between January 1999 December 201...