Methylselenol has been implicated as an active metabolite for the anticancer effect of selenium in part through the induction of cancer cell apoptosis. Since inactivation of the AKT/protein kinase B negative regulator gene PTEN (phosphatase and tensin homologue deleted on chromosome 10) is common in prostate cancer (PCa), we compared PTEN wild-type DU145 PCa cells (low basal AKT activity) with ...

BACKGROUND Selenium is a central determinant of antioxidative glutathione peroxidase 1 (GPx-1) expression and activity. The relevance of selenium supplementation on GPx-1 in coronary artery disease (CAD) needs to be established. We assessed the effect of selenium supplementation on GPx-1 in cell culture and on endothelial function in a prospective clinical trial. METHODS Human coronary artery...

PURPOSE This study was designed to examine the constrictive potential of C-Phycocyanin (C-PC) in regulating changes imposed on gene expression in the selenite-induced cataract model. METHODS Wistar rat pups were divided into three groups of eight each. On P10, Group I received an intraperitoneal injection of normal saline. Groups II and III received a subcutaneous injection of sodium selenite...

Background: Diabetes-related dysfunctions are the major causes of mortality and morbidity for diabetic patients. Objectives: Selenium is a potent antioxidant. In the present study, we examined antioxidative activities of sodium selenite and possible protective effect of it on serum, liver and kidney lipid peroxidation and glutathione in alloxan-induced type 1 diabetic rats. Materials and Method...

Several studies have suggested that angiotensin converting enzyme inhibitors retard the process of cataractogenesis by scavenging free oxygen radicals. The present study sought to assess the efficacy of the ACE inhibitor Lisinopril in preventing selenite-induced cataractogenesis in an experimental setting. The in vitro phase of the study was performed on lenses from wistar rats incubated for 24...

Two hundred and forty laying hens were fed diets supplemented with vitamin C and selenium (Se). Vitamin C was added at 0 or 200 mg/kg, and Se was added as sodium selenite or selenized yeast at 0.3 mg/kg. The feed intake and egg production were measured, and egg quality parameters were determined. Supplementation of the basal diet with Se significantly increased the laying performance; however, ...

Escherichia coli growing under anaerobic conditions produce H(2) and CO(2) by the enzymatic cleavage of formate that is produced from pyruvate at the end of glycolysis. Selenium is an integral part of formate dehydrogenase H (FDH H), which catalyses the first step in the formate hydrogen lyase (FHL) system. The genes of FHL system are transcribed only under anaerobic conditions, in the presence...

The common selenium oxoanions selenite (SeO3(2-)) and selenate (SeO4(2-)) are toxic at intake levels slightly below 1 mg day(-1). These anions are currently monitored by a variety of traditional analytical techniques that are time-consuming, expensive, require large sample volumes, and/or lack portability. To address the need for a fast and inexpensive analysis of selenium oxoanions, we present...

cataract is clouding of the eye lens that reduces the amount of incoming light and results in deteriorating vision. blindness is thought to reach 75 million by 2020. of these, unoperated cataract may be expected to account for at least 35 million. thus, the burden of cataract is increasing remorselessly. embelica officinalis is reported to have a very good antioxidant property and thus we hypot...

The administration of radioprotective compounds is one approach to prevent radiation damage in normal tissues. Thus, radioprotective compounds are important in clinical radiotherapy. Selenium is one radioprotective compounds that has been widely used in clinical studies of radiotherapy. However, evidence regarding the effectiveness of selenium use in radiotherapy and the mechanisms through whic...