Emerging medical technologies for effective and lasting repair of articular cartilage include delivery of cells or cell-seeded scaffolds to a defect site to initiate de novo tissue regeneration. Biocompatible scaffolds assist in providing a template for cell distribution and extracellular matrix (ECM) accumulation in a three-dimensional geometry. A major challenge in choosing an appropriate sca...

A self-engineering (SE) system is an ability designed and built into a which allows it to respond functionality lost automatically restore fully or partially maintain its availability. Examples include self-healing, self-repair, self-reconfiguring, built-in redundancy self-adapting systems. SE systems aim increase products useful life extend use phase. In previous research complexity framework ...

Long-lived sensor network applications must be able to self-repair and adapt to changing demands. We introduce a new approach for doing so: Constraint and Restoring Force. CRF is a physics-inspired framework for computing scalar fields across a sensor network with occasional changes. We illustrate CRF’s usefulness by applying it to gradients, a common building block for sensor network systems. ...

This paper gives a brief summary of our experience in applying a physics-style approach for analyzing the behavior of structured overlay networks that deploy self-organization and self-repair policies. Such systems are not always simple to model analytically and simulation of scales of interest can be prohibitive. Physicists deal with scale by characterizing a system using intensive variables, ...

Software systems nowadays are becoming increasingly complex and vulnerable to all sorts of failures and attacks. There is a rising need for robust self-repairing systems able to restore full functionality in face of internal and external perturbations, including those that affect their own code base. However, it is difficult to achieve code self-repair with conventional programming models. We p...

Self-healing software is one of the challenges issues for IST research. The WS-Diamond project aims at making a step in this direction by developing a framework for self-healing Web Services. In this paper, we present the overall goals of the project, namely: i) defining an operational framework for self-healing service execution of conversationally complex Web Services, where monitoring, detec...

PALB2 is essential for BRCA2 anchorage to nuclear structures and for homologous recombinational repair of DNA double-strand breaks. Here, we report that the N-terminal coiled-coil motif of PALB2 regulates its self-association and homologous recombination. Monomeric PALB2 shows higher efficiency to bind DNA and promotes RAD51 filament formation with or without the inhibitory effect of Replicatio...