During the last fifteen years, semicarbazones have been extensively investigated for their anticonvulsant properties. 4-(4-Flurophenoxy) benzaldehyde semicarbazone (C0102862, V102862) was discovered as a lead molecule and is being developed as a potent antiepileptic drug, with maximal electroshock (MES) ED₅₀ of i.p. 12.9 mg kg⁻¹. In MES (oral screen), this compound has a protective index (PI = ...

Acetophenone 2’,4’-dihydroxy semicarbazone (A24DHS) as a photometric reagent for the extractive spectrophotometric determination of Molybdenum (VI) is presented in this paper. The reagent A24DHS gave instantaneous and stable yellow colour with Molybdenum (VI) in the pH range 1.6 to 2.4. The system obeys Beer’s law in the concentration range of 1.0 μg/mL to 8.0 μg/mL at 370 nm. The Limit of Dete...

Diphtheria toxin is a single-chain protein toxin that invades human cells by receptor-mediated endocytosis. In acidic endosomes, its translocation domain inserts into endosomal membranes and facilitates the transport of the catalytic domain (DTA) from endosomal lumen into the host cell cytosol. Here, DTA ADP-ribosylates elongation factor 2 inhibits protein synthesis and leads to cell death. The...

The reaction of NiII acetate tetra-hydrate with 4-methyl-2-(1,2,3,4-tetra-hydro-naphthalen-1-yl-idene)hydrazinecarbo-thio-amide in a 2:1 molar ratio and recrystallization from di-methyl-formamide yielded the title compound, [Ni(C12H14N3S)2]·C3H7NO. The ligands act as monoanionic κ2N1,S-donors, forming five-membered metallarings. The NiII ion is fourfold coordinated in a distorted square-planar ...

The new title 4-thia-zolidinone derivative, C16H21N3O3S, was obtained from the cyclization reaction of 4-methyl-3-thio-semicarbazone and dimethyl acetyl-enedi-carboxyl-ate (DMAD). The cyclo-hexyl-idene ring has an envelope conformation with the stereogenic centre C atom as the flap. Its mean plane makes a dihedral angle of 56.23 (9)° with the thia-zolidine ring mean plane. In the crystal, mol-e...

The asymmetric unit of the title compound, [Fe(C(5)H(5))(C(7)H(8)N(3)S)], consists of two crystallographically independent mol-ecules, A and B. The cyclo-penta-dienyl (Cp) rings in both mol-ecules adopt an eclipsed conformation and are parallel to each other, forming dihedral angles of 2.5 (3) and 1.1 (3)°, respectively. The mean plane of the semicarbazone group is coplanar with the attached Cp...

A series of coordination compounds have been prepared with tridentate Schiff base ligands, 2 ethyl-[(hydroxy propyl)]3, 1 (4H) quinazoline4-semicarbazone [EHPQS) and 2-ethyl-[(hydroxy propyl)]3, 1 (4H) quinazoline4-thiosemicarbozone [EHPQT]. The obtained complexes were characterized by molar mass, elemental analysis, infrared spectra, electronic spectra, magnetic susceptibility molar conductanc...