Understanding infertility and sterility requires knowledge of the molecular mechanisms underlying sexual reproduction. We have found that male mice deficient for the gene encoding the protease inhibitor protease nexin-1 (PN-1) show a marked impairment in fertility from the onset of sexual maturity. Absence of PN-1 results in altered semen protein composition, which leads to inadequate semen coa...

Biological effects of extracts of Dolichos biflorus seeds and Amaranthus spinosus roots administered at two different doses (25 mg of D.biflorus seeds and 25 mg of A.spinosus roots; 50mg of D.biflorus seedsand 50 mg of A.spinosus roots) for 10 consecutive days were studied in the accessory sex organs of adult male rats. The observed adverse effect on organs weight, protein content and concentra...

Sixty-four steer calves were individually fed in a 181-day experiment to determine their gain, feed efficiency, plasma urea-N and seminal vesicle response following implantation with 30 mg of either stilbene, estriol, estrone, 16-estradiol, c~-estradiol or diethylstilbestrot (DES). Half of the steers were fed a constant level and the remaining half were fed a declining level of supplemental pro...

New supportive evidence is advanced in favor of the hypothesis that the enzymic coagulation of guinea pig semen involves transamidase reactions that result in the formation of gamma-glutamyl-epsilon-lysine intermolecular cross linkages between molecules of a basic protein in seminal vesicle secretion. The dipeptide gamma-glutamyl-epsilon-lysine was isolated in large quantities from proteolytic ...

The purpose of present study was to evaluate the testes and epididymides mediated reversible contraceptive efficacy of ethanol extract of Tinospora cordifolia stem at the dose level of 400mg/kg. b.wt./rat/day. Oral treatment of 60 days caused significant reduction in number of spermatozoa in cauda epididymides as well as in testis with a decreased in the motility of sperm collected from cauda e...

In male rabbits, injections of the female sex hormone result in marked increase in the size of ocular transplants of the prostate and seminal vesicles and a correlated elevation of the blood cholesterol. Other hormones, which cause an increase in the size of the transplants, do not show this correlation. The ingestion of cholesterol with conspicuous increase of the blood cholesterol, has no eff...

The following acanthocolpid species are reported from New Caledonia. Acaenodera nautili sp. n. from Conger cinereus Rüppel differs from other Acaenodera species in details of the body-spination, the sucker-ratio and the bipartite seminal vesicle; Stephanostomum murielae sp. n. from Carangoides hedlandensis (Whitley) differs from most species of Stephanostomum in the average of 36 circum-oral sp...

immune infertility, in terms of reproductive failure, has become a serious health issue involving approximately 1 out of 5 couples at reproductive age. semen that is defined as a complex fluid containing sperm, cellular vesicles and other cells and components, could sensitize the female genital tract. the immune rejection of male semen in the female reproductive tract is explained as the failur...

At ejaculation, human sperm are considered to be mechanically trapped and become immotile in the semen coagulum by binding to semenogelins (Sgs) from the seminal vesicle and zinc ions from the prostate. However, the physiological combined roles of the protein and heavy metal on sperm motility are unknown. Here, we have first demonstrated that Sg I alone, which does not form the semen coagulum w...

The occurrence of membrane vesicles along the male reproductive tract and in the ejaculated semen appears as a common feature among different species, including humans. Indeed, prostasomes (prostate-derived vesicles) were first described in human semen in 1978 (Ronquist et al, 1978), and vesicular structures similar to prostasomes were also found in the seminal plasma of rabbit (Davis, 1978), r...