BACKGROUND Nonsteroidal anti-inflammatory drugs (NSAIDs) exacerbate various forms of urticaria by a nonallergic mechanism involving inhibition of cyclooxygenases. OBJECTIVES To assess safety of cyclooxygenase inhibitors in patients with chronic idiopathic urticaria (CIU) and NSAID sensitivity and to evaluate a role of cysteinyl leukotriene metabolism and mast cell activation in sensitivity to...

Skin exfoliators, specifically alpha and beta hydroxy acids, have been shown to improve overall skin health the clinical signs of aging. A micropeeling cream was developed with acids a brown algae extract efficacy tolerability were evaluated in two parts. In first part pre-clinical investigation, placebo control by ELISA, immunostaining, qPCR an activity assay using ex vivo vitro models. second...

aim: despite the evidence suggesting the positive impact of the immediate mother-newborn skin-to-skin contact (scc), it has not yet been adopted to use for healthy newborn in iran. no study has explained the reasons. this study aimed to survey midwives' opinions about the predisposing factors in scc at birth in tehran hospitals in 2014.method: the samples, in this cross sectional descripti...

9–12 July 2003 Helsinki, Finland Exog Dermatol 2003;2:70–112 DOI:10.1159/000074109 Basel · Freiburg · Paris · London · New York · Bangalore · Bangkok · Singapore · Tokyo · Sydney D ow nl oa de d by : 54 .1 91 .4 0. 80 9 /1 7/ 20 17 2 :1 4: 57 P M Symposium 1: Prediction of Irritancy In vivo Irritation Models: Beyond Bioengineering Techniques – New Non-Invasive Approaches Fluhr, J. . . . . . . ....

To test whether heat-sensitive receptors participate in the cutaneous vascular responses to direct heating, we monitored skin blood flow (SkBF; laser Doppler flowmetry) where the sensation of heat was induced either by local warming (T(Loc); Peltier cooling/heating unit) or by both direct warming and chemical stimulation of heat-sensitive nociceptors (capsaicin). In part I, topical capsaicin (0...

Papillomaviruses have been linked to several skin disorders in the dog. In order to have a suitable diagnostic tool for canine papillomavirus detection, eight PCRs with published primer combinations were evaluated. The most sensitive PCR was used to demonstrate that papillomavirus DNA can be detected on nonlesional skin of dogs.

Costimulatory signals and growth factor signals play a key role in commanding T cell activation and T cell effector function. However, how costimulatory signals and growth factor signals interact and integrate into the activation program of CD4(+) and CD8(+) T cells during the allograft response remains poorly defined. In the present study we found that either CD4- or CD8-deficient mice can vig...

Temperature-sensitive transient receptor potential (TRP) channels such as TRPA1 and TRPV1 have been identified as downstream ion channel targets in the transduction of itch. As a member of the temperature-sensitive TRP family, the Ca2+-permeable nonselective cation channel TRPV3 is expressed abundantly in skin keratinocytes. Recent identification of gain-of-function mutations of human TRPV3 fro...

Detecting the human skin and its analysis has number of important applications. This is a challenging task as. in images, the skin color is quite sensitive to the chrominance and intensity of the pixels. So the techniques with a single model for skin fail to cope up with the variation in skin colors because of ethnicity, age, lighting etc. This paper proposes a novel technique for skin detectio...

Sensitive skin is a frequently mentioned cosmetic complaint. Addition of a biomimetic of neuromediator has recently appeared as a promising new way to cure skin care product problems. This study was aimed to assess the inhibitory effect of a biomimetic lipopeptide derived from proopiomelanocortin (bPOMC) on capsaicin-induced sensory irritation in human volunteers and also to compare its protect...