Secretion of glucocorticoids seems to control stress-induced sensitization of the behavioral effects of drugs of abuse by acting on the mesencephalic dopaminergic transmission, the principal neural substrate of sensitization. In order to investigate the mechanisms of this interaction between glucocorticoids and dopamine, we studied the sensitization of the increase in extracellular concentratio...

Background: Specific sensitization characterizes increased serum level of IgE to different groups of allergens (food, dust, domestic and contact). Characteristic of specific sensitization changes with age of patient. Spectrum of specific sensitization determined environmental factors, conditions of habitation. Objective: objective was to research characteristic of specific sensitization in pati...

BACKGROUND The relation between secondhand tobacco smoke (SHS) exposure and the development of allergic sensitization in children is unclear. The aim of this study was to determine whether maternal smoking during pregnancy and postnatal SHS exposure contributes to the development of allergic sensitization in children and adolescents up to 16 years of age. METHODS We included 3316 children fro...

BACKGROUND/PURPOSE Environmental factors, different ages, and detection methods might affect the profiles of allergy sensitization and confound the diagnosis of allergic diseases. The purpose of this study was to investigate the different profiles of allergen sensitization in different ages, geographic areas, and detection methods. METHODS We analyzed the patients who received allergen sensit...

Repeated exposure to drugs of abuse enhances the motor-stimulant response to these drugs, a phenomenon termed behavioral sensitization. Animals that are extinguished from self-administration training readily relapse to drug, conditioned cue, or stress priming. The involvement of sensitization in reinstated drug-seeking behavior remains controversial. This review describes sensitization and rein...

Background Asthma and allergic rhinitis are a global health burden. Inhalant allergens worsen the symptoms and clinical manifestations of asthma and allergic rhinitis. Skin prick test is the gold standard for diagnosing allergen sensitization but is associated with some limitations. In contrast, in vitro serum-specific immunoglobulin E (SSIgE) test is convenient and is not associated with an an...

OBJECTIVE We evaluated a workplace preventive program's effectiveness, which emphasized skin and respiratory protection, workplace cleanliness, and beryllium migration control in lowering beryllium sensitization. METHODS We compared sensitization prevalence and incidence rates for workers hired before and after the program using available cross sectional and longitudinal surveillance data. ...

objective: asthma is an airway complex disease defined by reversible airway narrowing and obstruction, chronic airway inflammation, airway hyperresponsiveness, and tissue remodeling. the purpose of this study was to determine the effect of brassica napus l. (b. napus) on airway pathologic changes in a rat model of asthma. materials and methods: twenty-four rats were divided into 4 groups: contr...

background: cuminum cyminum fruit essential oil (feo) dose-dependently can attenuate the expression of morphine tolerance and dependence in morphine-dependent mice. objective: in this study, the effects of cuminum cyminum feo on acquisition and expression of morphine-induced conditioned place preference (cpp) in morphine-sensitized mice were studied. methods: repeated subcutaneous (s.c.) admini...

introduction: the diagnostic work-up of allergic rhinitis (ar) is first and foremost based on the combination of clinical history data and results of skin prick tests (spt). other tests, including specific ige measurement, nasal challenge, and, as a third option, component resolved diagnosis or basophil activation test, may be useful when the diagnosis is difficult because of polysensitization ...