Adult respiratory distress syndrome (ARDS) is rarely reported in association with typhoid fever despite the fact that sepsis is a common manifestation and endotoxemia has been described in this multisystem condition. We describe the course of a patient with ARDS and typhoid fever. With conventional treatment of the lung injury and with specific antimicrobial therapy, the patient survived. Recen...

Sepsis is a clinical syndrome characterized by systemic infl ammation and widespread tissue injury. It results from an excessive infl ammatory host response to an infective agent which, when generalized, involves normal tissue not originally affected by the causative organism(s) [1]. There is massive release of infl ammatory mediators, causing leukocytes to accumulate in organs distant from the...

Sepsis is a major life‐threatening health‐care problem. According to statistics, there are 20–30 million new cases of sepsis worldwide annually, which causes equivalent deaths from acute myocardial infarction and kills more people than breast cancer, stroke, and AIDS combined. About 41% of cases of sepsis progress to multiple organ dysfunction syndrome (MODS), resulting in mortality as high as ...

Sepsis and sepsis syndrome are leading causes of mortality throughout the world. It is widely held that sepsis represents a dysregulated innate immune response to an offending pathogen. This immune response is often initiated via microbial products signaling through TLRs expressed on host immune cells. There is increasing evidence that this innate response can be dramatically influenced by the ...

Objectives: To evaluate the specificity of Procalcitonin (ProCT) as marker of neonatal infection. Materials and Methods: The study includes 131 newborns admitted to the NICU. ProCT was determined in 5 groups of newborn with Sepsis, Asphyxia, Respiratory Distress Syndrome (RDS), Localized Infection and in uninfected patients. Results: Serum ProCT values were significatively high in sepsis group ...

Background. While often first treated in the emergency department (ED), identification of sepsis is difficult. Electronic medical record (EMR) clinical decision tools offer a novel strategy for identifying patients with sepsis. The objective of this study was to test the accuracy of an EMR-based, automated sepsis identification system. Methods. We tested an EMR-based sepsis identification tool ...

The present study compares neonatal outcome after preterm delivery of infants in pregnancies complicated by the HELLP syndrome or severe preeclampsia (PS). The maternal and neonatal charts of 71 out of a total of 409 pregnancies that were complicated by hypertensive disorders at Severance hospital between January 1995 and December 2004 were reviewed. Twenty-one pregnancies were complicated by H...

Granulocytic fragments have been described in the peripheral blood of patients with sepsis and the systemic inflammatory response syndrome (SIRS). Although initially proposed as a morphologic clue for distinguishing the leukoerythroblastosis of sepsis from that of myelophthisis or marrow replacement by tumor, granulocyte-derived fragments may be part of a spectrum of cellular fragmentation asso...

Sepsis is a complicated syndrome that manifests within the complex adaptive system that is the human body. Complexity theory and the recently emerged applied complexity science illustrate these phenomena and the body's response in light of understanding these complex systems. Provision of careful observation by the nurse may recognize signs of moving into a nonadaptive or declining status, faci...

Multiorgan failure (MOF) represents the leading cause of death in patients with sepsis and systemic inflammatory response syndrome (SIRS) following severe trauma. The underlying immune response is highly complex and involves activation of the complement system as a crucial entity of innate immunity. Uncontrolled activation of the complement system during sepsis and SIRS with in excessive genera...