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There is no single proven therapy that prolongs hepatic transplant-free survival in patients with primary sclerosing cholangitis (PSC). Oral vancomycin (OV) has shown some benefit small pediatric and adult series. We describe the effect of OV on onset PSC at our tertiary hospital. This a single-center, retrospective, descriptive case series involving (<21 years diagnosis) from 2001 till 2021...

Hemigrammocapoeta menderesensis is distinguished from all other species of Hemigrammocapoeta in Anatolia by the following combination of characters (none unique to the species): lateral line incomplete; 6-17 perforated scales and 36-41 +1-2 scales in lateral series; 7½-8½ scale rows between lateral line and dorsal-fin origin, 3-4 scale rows between lateral series and anal-fin origin; dorsal fin...

A library of thirty eight novel thiazolo[5,4-f]quinazolin-9(8H)-one derivatives (series 8, 10, 14 and 17) was prepared via the Hügershoff reaction and a Cu catalyzed intramolecular C-S bond formation, helped by microwave-assisted technology when required. The efficient multistep synthesis of the key 6-amino-3-cyclopropylquinazolin-4(3H)-one (3) has been reinvestigated and performed on a multigr...

primary sjögren's syndrome (pss) is a common autoimmune disease involving abnormal th17 activation. the aim of the current study was to investigate the immunosuppression effect of cyclosporine a (cys a), a potent immunosuppressor on the proliferation and activation of t cells, on the activation of th17 cells. blood samples from both inactive and active pss patients as well as healthy controls w...