Celiac disease is emerging in India and has become a public health problem. Almost 6-8 million Indians are estimated to have celiac disease. While there is a large pool of patients with celiac disease in India, until now, only a fraction of them have been diagnosed. With increasing awareness about celiac disease amongst health care providers and the general population, a massive increase in the...

From the Department ofPathologe and Institute ofInfectious Diseases,t University ofMilano, "L. SACCO" Hospital, Milan, Italy; Department ofPathologj and Institute ofHematology,§ University ofPavia, Policlinico San Matteo-IRCCS, Instituto Ricovero & Cura Carattere Scientifico, Research Unit, Pavia, Italy; Department ofPathology,7 Columbia University College of Physicians and Surgeons, New York, ...

OBJECTIVES After participating in the continuing education activity, primary care physicians should be able to: 1. Identify the common clinical manifestations of celiac disease 2. Develop an algorithmic approach to the patient with suspected celiac disease 3. Understand key components of the gluten-free diet 4. Develop a long-term plan for managing a patient with celiac disease 5. Identify at-r...

CONTEXT The association between celiac disease and pancreatitis is sparsely reported. Celiac disease may remain asymptomatic or may have atypical features, and its diagnosis in pancreatitis may not be obvious. It is more than mere chance association that explains the occurrence of pancreatitis in celiac disease. Malnutrition, papillary stenosis and immunopathogenetic mechanisms contribute to th...

Background: The togetherness of invagination with celiac disease is an extremely rare condition especially in children. However, invagination may be the presenting symptom of celiac disease. Moreover, recurrent invaginations have been also reported in patients with celiac disease. Aim: To increase the awareness of clinicians about togetherness of these conditions. Case Presentation: Herein, we ...

Celiac disease (gluten sensitive enteropathy) is a common disorder affecting both children and adults. As many people with celiac disease do not present with the classic malabsorptive syndrome, delays in diagnosis are common. Dental enamel defects and recurrent aphthous ulcers, which may occur in patients with celiac disease, may be the only manifestation of this disorder. When dentists encount...

OBJECTIVES There are significant geographical differences in the prevalence and incidence of celiac disease that cannot be explained by HLA alone. More than 40 loci outside of the HLA region have been associated with celiac disease. We investigated the roles of these non-HLA genes in the development of tissue transglutaminase autoantibodies (tTGA) and celiac disease in a large international pro...

BACKGROUND Celiac disease is an autoimmune disease that affects approximately 1% of the US population. Disease is characterized by damage to the small intestinal lining and malabsorption of nutrients. Celiac disease is activated in genetically susceptible individuals by dietary exposure to gluten in wheat and gluten-like proteins in rye and barley. Symptoms are diverse and include gastrointesti...

OBJECTIVE The objective of this evidence-based analysis was to evaluate the clinical utility of serologic testing for celiac disease in asymptomatic individuals presenting with one of the non-gastrointestinal conditions evaluated in this report. The clinical utility was based on the effects of a gluten-free diet (GFD) on outcomes specific to each of these conditions. The prevalence of celiac di...

INTRODUCTION Celiac crisis is a life-threatening complication of celiac disease that is rarely described in adults. CASE REPORT We report the case of a 31-year-old man with celiac crisis as a first manifestation of celiac disease. The patient presented with severe diarrhea, metabolic acidosis, and electrolyte disturbances accompanied by electrocardiographic alterations. A satisfactory clinica...