Two experiments were conducted to compare the effects of a progesterone-estradiol implant (PEI) with no implant (NI) and 20 g of copper oxide needles (CuON) with no CuON on grazing, subsequent feedlot performance, and selected serum constituents of steers. In Exp. 1, 114 Limousin crossbred yearling steers (317 kg average initial BW) were stocked continuously on Acremonium coenophialum-infected ...

PURPOSE Copper in serum supports angiogenesis and inhibits replication of wild-type HSV-1. Copper chelation is currently being investigated as an antiangiogenic and antineoplastic agent in patients diagnosed with cancer. Herpes simplex virus-derived oncolytic viruses (oHSV) are being evaluated for safety and efficacy in patients, but several host barriers limit their efficacy. Here, we tested w...

A fluorescence turn-on probe for Cu(2+) based on the novel copper-mediated dihydrorosamine oxidation reaction has been constructed and employed in the detection of Cu(2+) in water, new born calf serum, and living cells, and the new copper-mediated dihydrorosamine oxidation reaction likely proceeds by a copper redox mechanism.

Background: Psoriasis is a common and chronic inflammatory skin disease that has profound adverse effects on patients’ wellbeing. Trace elements are essential to biochemical processes in the body and are involved in immunological and inflammatory reactions such as keratinization and melanin formation. The aim of this study was to evaluate the essential metals in psoriasis in comparision with he...

Clinically and electrophysiologically confirmed cases of primary retinitis pigmentosa have been investigated regarding their copper metabolic state. It is observed that these patients show a normal or near normal serum copper concentration, very low plasma caeruloplasmin concentration, and a very high copper urinary excretion. A similarity between this condition and hepatolenticular degeneratio...

W ilson disease in an autosomal recessive disorder usually presenting with hepatic, neurologic and psychiatric manifestations. Other features include cholelithiasis, nephrolithiasis, osteoarthritis and hemolysis. We report a case of haemolytic anaemia and lab findings suggestive of Wilson disease lacking the other clinical manifestations of the disease A 16 year old male presented with generali...

Prompt serum copper and zinc in addition to vitamin B12 levels should be measured in patients suffering from refractory anemia with neurological symptoms. A timely copper supplementation can help revert the hematological and possibly the neurological manifestations.

The biochemical and histopathological alterations in the blood and liver of the teleost fish, Anabas testudineus subjected to two sub-lethal concentrations of copper and the capacity of vitamin C to counteract the toxicity induced perturbations were investigated. The 96 hour LC 50 value of copper for A. testudineus was determined by Probit method and was found to be 1.74 mg/L. The blood and liv...

BACKGROUND In Wilson disease, copper is not sufficiently excreted into bile due to the absence or malfunction of the Wilson protein copper ATPase in the excretory pathway of hepatocytes. Copper is found in sweat. It is unknown if the Wilson protein plays a role in copper excretion into sweat. It is the aim of this study to investigate Wilson protein expression in sweat glands and analysing its ...

The limits of copper homeostatic regulation in humans are not known, making it difficult to define the milder effects of early copper excess. Furthermore, a robust assay to facilitate the detection of early stages of copper excess is needed. To address these issues, we assessed changes in relative mRNA abundance of methallothionein 2A (MT2A), prion (PrP), amyloid precursor-like protein 2 (APLP2...