Although the clearance of endogenous creatinine as a measure of the glomerular filtration rate has been much criticized, it remains the only possible measure where repeated or continuous investigation is needed, and has already yielded much useful information. When we started to use it, however, it became apparent that while the estimation of creatinine in urine was satisfactory, that of plasma...

Creatinine amidohydrolase is used to measure serum creatinine in a totally enzymatic procedure. Creatine, produced by hydrolysis, is acted upon by creatine kinase, and then by pyruvate kinase and lactate dehydrogenase, to result in a change in absorbance at 340 nm. The amount of creatinine present is related to the rate of change in A340 and is determined from a standard curve. Absorbance and c...

conclusions vancomycin nephrotoxicity is common but usually reversible and has readily manageable adverse effect. urine kim-1 was not more accurate than serum or urine creatinine in detecting vancomycin nephrotoxicity in our study population. results thirteen out of the 52 recruited patients (25%) developed nephrotoxicity, with a mean ± standard deviation onset of 11.46 ± 7.56 days. furosemide ...

BACKGROUND Accurate renal function measurements are important in the diagnosis and treatment of kidney diseases. In contrast to creatinine, the production of serum cystatin C has been extensively reported to be unaffected by body muscle mass, age, gender, and nutritional status. METHODS Our study included 37 samples from diabetic chronic kidney disease (CKD) patients for whom serum creatinine...

OBJECTIVE To evaluate the validity of the International Classification of Diseases, Tenth Revision (ICD-10) code N17x for acute kidney injury (AKI) in elderly patients in two settings: at presentation to the emergency department and at hospital admission. DESIGN A population-based retrospective validation study. SETTING Southwestern Ontario, Canada, from 2003 to 2010. PARTICIPANTS Elderly...

OBJECTIVE A generic cisplatin formulation has replaced the brand-name formulation since November 2003 in our hospital. We retrospectively assessed the renal toxicity caused by the brand-name and generic cisplatin formulations. METHODS The medical records of patients with thoracic malignancy who were treated at our hospital between November 2000 and April 2008 were reviewed. In total, 1296 eli...

BACKGROUND Hypertensive disorders are the most common in pregnancy. Several studies showed a positive correlation between elevated maternal serum uric acid (UA), serum creatinine and adverse maternal and fetal outcomes, but only a few studies are available on serum cystatin C and maternal and fetal outcomes. The present study was undertaken to study the association of serum UA, creatinine and c...

Aim: To analyze serum uric acid, urea, and creatinine levels in Oral Submucous Fibrosis patients and compare them with those of healthy controls. Materials and Methods: 40 OSMF patients and 20 controls had serum uric acid, urea and creatinine levels measured using spectrophotometer. The data obtained was analyzed using the Statistical Package for the Social Sciences, version 19.0 (SPSS 19). Sta...

BACKGROUND Low skeletal muscle mass is associated with insulin resistance and metabolic syndrome. Serum creatinine may serve as a surrogate marker of muscle mass, and a possible relationship between low serum creatinine and type 2 diabetes has recently been demonstrated. We aimed to validate this finding in a population of Caucasian morbidly obese subjects. METHODS Cross-sectional study of 1,...

in the present study, we investigated the effects of the aqueous extract of mucuna pruriens against gentamicin (100 mg kg -1 per day for six days) induced oxidative stress and nephrotoxicity in rats. administration of gentamicin to rats induced a marked renal failure, characterized by a significant increase in urine volume and serum creatinine and urea levels. there was a significant decrease i...