BACKGROUND Evidence is emerging that haptoglobin, an acute phase protein with immunomodulatory properties, is expressed by the endometrium of various species. The present study describes an in-depth investigation of haptoglobin expression and release in the rabbit reproductive tract and in preimplantation embryos. METHODS The full-length cDNA sequence of rabbit haptoglobin was determined by r...

Haptoglobin (Hp) is a mammalian serum glycoprotein showing a genetic polymorphism with three types, 1-1, 2-2 and 1-2. Hp appears to conserve the recycling of heme-iron by forming an essentially irreversible but non-covalent complex with hemoglobin which is released into the plasma by erythrocyte lysis. As an important consequence, Haptoglobin-Hemoglobin complex (Hp-Hb) shows considerable antiox...

Background: Endocan, also known as specific molecule-1 in endothelial cell, plays an important role dysfunction and inflammatory reaction [1, 2]. Serum endocan, a new biochemical marker of dysfunction, the development cardiovascular disease (CVD). In this study, we investigate there was difference serum CYP2R1, Haptoglobin protein levels between patients with DM (+) PAH those (-) PAH. Methods: ...

Eimeria türlerinin neden olduğu koksidiyoziste kuzu ve oğlaklarda diyareye olan etkenlerden biridir. Kuzu oğlaklarında akut koksidiyozis tedavisinde toltrazuril’in oldukça etkili bilinse de canlıda nasıl etkiler oluşturduğu ile ilgili bilgiler sınırlıdır. Bu nedenle bu çalışmada Honamlı ırkı oğlakların doğal koksidiyozisinin toltrazuril uygulamasının hayvanda etkiler, serum oksidatif stres düze...

The objective of this study was to investigate the effect of transportation and commingling on measures of the acute-phase protein response in newly weaned beef calves. Thirty-two (Exp. 1; average BW = 266 +/- 20.8 kg) and thirty-six (Exp. 2; average BW = 222 +/- 34.6 kg) Brahman-crossbred calves were randomly allotted to one of four treatments (2 x 2 factorial arrangement [transportation x com...

BACKGROUND Serum haptoglobin (Hp) and haptoglobin matrix metalloproteinase 9 complexes (Hp-MMP 9) have been identified as biomarkers with diagnostic potential in cattle with conditions resulting in an acute inflammatory response. The purpose of this study was to evaluate potential diagnostic applications of serum Hp and Hp-MMP 9 concentrations in calves with BRD and establish a timeline for the...

The haptoglobin genetic locus at 16q22 is polymorphic with two known classes of alleles, denoted 1 and 2 (1 ). The polymorphism is extremely common, with worldwide frequencies of the two alleles being approximately equal. However, there is considerable geographic and ethnic variation in the distribution of haptoglobin phenotypes (1 ). Over the past 3–4 years our laboratory has demonstrated that...

Haemophilus influenzae requires heme for growth and can utilize hemoglobin and hemoglobin-haptoglobin as heme sources. We previously identified two hemoglobin- and hemoglobin-haptoglobin-binding proteins, HgpA and HgpB, in H. influenzae HI689. Insertional mutation of hgpA and hgpB, either singly or together, did not abrogate the ability to utilize or bind either hemoglobin or the hemoglobin-hap...

Haptoglobin, the haptoglobin-hemoglobin receptor CD163, and the heme oxygenase-1 are proteins with a well-established function in the clearance and metabolism of "free" hemoglobin released during intravascular hemolysis. This scavenging system counteracts the potentially harmful oxidative and NO-scavenging effects associated with "free" hemoglobin, and, furthermore, elicits an anti-inflammatory...

The complete amino acid sequences and the disulfide arrangements of the two chains of human haptoglobin 1-1 were established. The alpha 1 and beta chains of haptoglobin contain 83 and 245 residues, respectively. Comparison of the primary structure of haptoglobin with that of the chymotrypsinogen family of serine proteases revealed a significant degree of chemical similarity. The probability was...