Leydig stromal cell tumor is a rare ovarian tumor that belongs to the group of sex-cord stromal tumors. They produce testosterone leading to hyperandrogenism. We present a 41yr old woman with symptoms of virilization and a mass of right adenex via ultra Sonography, and a rise of total and free serum testosterone. An ovarian source of androgen was suspected and a surgery performed. A diagnosis ...

Sex bias has been described nowadays in biomedical research on animal models, although sexual dimorphism has been confirmed widely under pathological and physiological conditions. The main objective of our work was to study the sex differences in constitutive autophagy in spinal cord and skeletal muscle tissue from wild type mice. To examine the influence of sex on autophagy, mRNA and proteins ...

Mesonephric cell migration and seminiferous cord formation are critical processes in embryonic testis development at the time of male sex determination. Extracellular growth factors shown to influence seminiferous cord formation such as neurotropin-3 utilize in part the phosphotidylinositol 3-kinase (PI3K) signal transduction pathway. The current study investigates the hypothesis that the PI3K ...

BACKGROUND Sex hormone binding globulin (SHBG), a glycoprotein produced by hepatocytes that transports testosterone and other steroids in plasma, is a marker for developing metabolic syndrome and T2DM. SHBG is present in umbilical cord blood where it may be epigenetically regulated. This study was conducted to investigate whether the fetal environment, based on maternal pre-pregnancy weight, pr...

OBJECTIVES To assess in vivo the volume and the magnetization transfer magnetic resonance imaging (MRI)-detectable damage of the cervical cord gray matter in patients with relapsing-remitting multiple sclerosis (RRMS) and to evaluate whether such damage correlates with disability. DESIGN Cervical cord conventional and magnetization transfer MRI scans were acquired from 18 patients with RRMS (...

OBJECTIVES To evaluate the verbal interactions of parents with their infants in the first months of life and to test the hypothesis that reciprocal vocalizations of mother-infant dyads would be more frequent than those of father-infant dyads. METHODS This prospective cohort study included 33 late preterm and term infants. Sixteen-hour language recordings during the birth hospitalization and i...

Recent studies have revealed a link between estradiol (E2) and glucose homeostasis. We aimed to assess the association between cord blood hormone levels and the risk of gestational diabetes mellitus (GDM).A total of 204 pregnant women with GDM and 204 pregnant women without GDM (control) were included in the study. Maternal GDM were diagnosed using a 75 g oral glucose tolerance test at 24 to 26...

Sertoli-Leydig cell tumor (SLCTs) of the ovary, also known as androblastoma, is a rare neoplasm from group sex cord-stromal tumors ovary. They account for less than 0.5% all ovarian tumors. typically occur in young and reproductive women patients usually present with abdominal swelling or pain. A case 35-year-old multiparous female presented mass, ultrasonography revealed large abdomino-pelvic ...