Interpretation of human genomes is a major challenge. We present the Scripps Genome ADVISER (SG-ADVISER) suite, which aims to fill the gap between data generation and genome interpretation by performing holistic, in-depth, annotations and functional predictions on all variant types and effects. The SG-ADVISER suite includes a de-identification tool, a variant annotation web-server, and a user i...

A Sylvester-Gallai (SG) configuration is a finite set S of points such that the line through any two points in S contains a third point of S. According to the Sylvester-Gallai Theorem, an SG configuration in real projective space must be collinear. A problem of Serre (1966) asks whether an SG configuration in a complex projective space must be coplanar. This was proved by Kelly (1986) using a d...

Objective The objective of this study was to examine the effect the provision of information about the physical and technological environment of the intensive care unit (ICU) had on whether patients felt discomfort during their ICU experience. Design and Setting The study used a quasi‐experimental design. Patients were selected through convenience sampling at a university hospital in Erzurum, T...

We have used an aequorin chimera targeted to the membrane of the secretory granules to monitor the free [Ca(2+)] inside them in neurosecretory PC12 cells. More than 95% of the probe was located in a compartment with an homogeneous [Ca(2+)] around 40 microM. Cell stimulation with either ATP, caffeine or high-K(+) depolarization increased cytosolic [Ca(2+)] and decreased secretory granule [Ca(2+)...

Although an increase in soil fertility is the most frequently reported benefit linked to adding biochar to soils, there is still a need to pursue additional research that will improve our understanding on the impact of soil fertility enhancement because the effect could vary greatly between switchgrass (Panicum virgatum, L) residues (USG) and switchgrass biochars (SG). We hypothesized that SG w...

Salivary gland function is regulated by both the sympathetic and parasympathetic nervous systems. Previously we showed that the basal sympathetic outflow to the salivary glands (SNA(SG)) was higher in hypertensive compared to normotensive rats and that diabetes reduced SNA(SG) discharge at both strains. In the present study we sought to investigate how SNA(SG) might be modulated by acute change...

AIMS/INTRODUCTION Undetected diabetes distress is a cause of concern. However, the lack of a validated questionnaire is a barrier to screening for diabetes distress. The aim of the present study was to examine the validity and reliability of the Chinese version of the Problem Areas in Diabetes scale (SG-PAID-C), and its association with sociodemographic and clinical parameters in patients with ...