BACKGROUND Myocardial contrast echocardiography (MCE) has been shown to have a potential for apparently reversible side effects related to the interaction of ultrasound with the contrast microbubbles, including premature ventricular contractions and microvascular leakage. We investigated the potential for high-dose MCE to induce histologically definable microlesions. METHODS Myocardial contra...

PURPOSE We have demonstrated that a 2'-O-methoxyethyl modified antisense oligonucleotide against the mouse growth hormone (GH) receptor (GHr) reduces GH binding and serum insulin-like growth factor-1 in normal mice. We tested whether this systemically delivered antisense oligonucleotide could inhibit neovascularization in mice with oxygen induced retinopathy (OIR). METHODS OIR was induced in ...

starting from the 6th century a.h., and especially starting from the mongol era onward, along with the flourishing of historiography, historical shāhnāmeh-composition also became a point of interest, and shāhnāmehs appeared with the aim of recording historical events. in the composition of these shāhnāmehs, ferdowsi’s shāhnāmeh was like a model for the shāhnāmeh-writers, and due to this the spi...

Bupha-Intr T, Wattanapermpool J, Peña JR, Wolska BM, Solaro RJ. Myofilament response to Ca and Na /H exchanger activity in sex hormone-related protection of cardiac myocytes from deactivation in hypercapnic acidosis. Am J Physiol Regul Integr Comp Physiol 292: R837–R843, 2007. First published October 12, 2006; doi:10.1152/ajpregu.00376.2006.—Compared to sham-operated controls, myofilaments from...

BACKGROUND Coronary artery disease predisposes to atrial fibrillation (AF), but the effects of chronic atrial ischemia/infarction on AF-related substrates are unknown. METHODS AND RESULTS Regional right atrial myocardial infarction (MI) was created in 40 dogs by ligating an artery that supplies the right atrial free wall and not the ventricles; 35 sham dogs with the same artery isolated but n...

Conventional resuscitation (CR) from hemorrhagic shock (HS) results in gut and liver hypoperfusion, organ and cellular edema, and vital organ injury. Adjunct direct peritoneal resuscitation (DPR) with dialysate prevents gut vasoconstriction, hypoperfusion, and injury. We hypothesized that DPR might also improve hepatocellular edema, inflammation, and injury. Anesthetized male SD rats were assig...

OBJECTIVES We tested the hypothesis that angiotensin II type 1 receptor blocker (ARB) may improve beta-adrenergic receptor (AR) coupling in heart failure (HF) after myocardial infarction (MI). BACKGROUND Beta-AR desensitization is one of the mechanisms underlying the transition from compensated to decompensated HF. Beta-adrenergic receptor kinase-1 (ARK1), which can be induced by protein kina...

Background/Aims: Endometrial thickening is a nonspecific finding in women with premenopausal bleeding. Though it is expected in the luteal phase of ovulatory cycle or with anovulatory bleeding, it can be due to hyperplasia, polyps, leiomyomas, or endometrial carcinoma. Three-dimensional ultrasonography is an imaging technique that allows unique ways of assessing uterine and adnexeal pathology. ...

Selective androgen receptor modulators (SARMs) now under development can protect against muscle and bone loss without causing prostate growth or polycythemia. 17β-Hydroxyestra-4,9,11-trien-3-one (trenbolone), a potent testosterone analog, may have SARM-like actions because, unlike testosterone, trenbolone does not undergo tissue-specific 5α-reduction to form more potent androgens. We tested the...