This study was undertaken to demonstrate capabilities of the pin-by-pin model used by the BARS code and to understand various effects of intra-assembly pin-by-pin representation of fuel power, bumup and temperature in calculational analysis of light water reactor rod ejection accidents (LWR REAs). Effects of pin-by-pin fuel power and bumup representation were investigated on the basis of calcul...

We present large-scale reproducible fabrication of multifunctional ultrasharp metallic structures on planar substrates with capabilities including magnetic field nanofocusing and plasmonic sensing. Objects with sharp tips such as wedges and pyramids made with noble metals have been extensively used for enhancing local electric fields via the lightning-rod effect or plasmonic nanofocusing. Howev...

Regnase-1 is an RNase that directly cleaves mRNAs of inflammatory genes such as IL-6 and IL-12p40, and negatively regulates cellular inflammatory responses. Here, we report the structures of four domains of Regnase-1 from Mus musculus-the N-terminal domain (NTD), PilT N-terminus like (PIN) domain, zinc finger (ZF) domain and C-terminal domain (CTD). The PIN domain harbors the RNase catalytic ce...

N ature is full of curves. So it is only natural that manmade devices meant to interact with nature emulate its elements of design. That is the line of reasoning behind the innovations of John Rogers, a member of the National Academy of Engineering and a professor of materials science at the University of Illinois, Urbana-Champaign. Rogers’ innovations have inspired an array of approaches to re...

OBJECTIVE To assess the magnitude and causes of over-diagnosis of prostatic intraepithelial neoplasia (PIN), as large differences are reported in the incidence of high-grade PIN, probably because of the variance in diagnosis and interpretation. PATIENTS AND METHODS Two urological pathologists prospectively reviewed 251 consecutive patients, received in consultation and who were diagnosed and ...

Plant development displays an exceptional plasticity and adaptability that involves the dynamic, asymmetric distribution of the phytohormone auxin. Polar auxin flow, which requires polarly localized transport facilitators of the PIN family, largely contributes to the establishment and maintenance of the auxin gradients. Functionally overlapping action of PIN proteins mediates multiple developme...

The problem of pain, since the beginning of this century, has been dominated by the concept that pain is purely a sensory experience. Yet it has a unique, distinctively unpleasant, affective quality that differentiates it from sensory experiences such as sight, hearing or touch. . . . The motivational-affective dimension of pain is brought clearly into focus by clinical studies on frontal lobot...