Side-chain oligo- and polyglutamylation represents an important posttranslational modification in tubulin physiology. The particular number of glutamate units is related to specific regulatory functions. In this work, we present a method for the synthesis of building blocks for the Fmoc synthesis of peptides containing main chain glutamic acid residues that carry side-chain branching with oligo...

The objective of this paper is the study of the equilibrium behavior of a population on the hierarchical group ΩN consisting of families of individuals undergoing critical branching random walk and in addition these families also develop according to a critical branching process. Strong transience of the random walk guarantees existence of an equilibrium for this two-level branching system. In ...

A recent numerical method has opened new opportunities in multidimensional population balance modeling. Here, this method is applied to a full three-dimensional population balance model (PBM) describing branching topology evolution driven by chain end to backbone coupling. This process is typical for polymer modification reactions, e.g., in polyethylene, where initially linear polymer chains un...

Cohesion properties of the binder matrix within asphalt mixes and adhesion characteristics of the asphalt binder and aggregate particles are the two major mechanisms resisting against cracking in asphalt mixes. This study is focused on estimating crack resistance of asphalt mixes at intermediate temperatures through evaluation of cohesion and adhesion properties of binder-aggregate systems usin...

OBJECTIVE Highly processed foods such as convenience foods usually have a high salt content and therefore might indirectly act as adipogenic due to an increasing consumption of sugar-containing beverages (SCB). We examined the association between dietary salt and body weight status. DESIGN We used data on urinary Na excretion as an indicator of dietary salt and BMI standard deviation score (B...

Flexible and dynamic supply chain network design problem has been studied by many researchers during past years. Since integration of short-term and long-term decisions in strategic planning leads to more reliable plans, in this paper a multi-objective model for a sustainable closed-loop supply chain network design problem is proposed. The planning horizon of this model contains multiple strate...