Midazolam is a short-acting benzodiazepine that is in wide clinical use as an anxiolytic, sedative, hypnotic, and anticonvulsant. Midazolam has been shown to inhibit ion channels, including calcium and potassium channels. So far, the effects of midazolam on cardiac human ether-à-go-go-related gene (hERG) channels have not been analyzed. The inhibitory effects of midazolam on heterologously expr...

We report here that osmotic effects and ionic effects are both involved in the NaCl-induced inactivation of the photosynthetic machinery in the cyanobacterium Synechococcus sp. PCC 7942. Incubation of the cyanobacterial cells in 0.5 M NaCl induced a rapid and reversible decline and subsequent slow and irreversible loss of the oxygen-evolving activity of photosystem (PS) II and the electron tran...

Objective(s) Four novel losartan analogues 5a-d were synthesized by connecting a dihydropyridine nucleus to imidazole ring. The effects of 5a and 5b on angiotensin receptors (AT') and L-type calcium channels were investigated on isolated rat aorta. Materials and Methods Aortic rings were pre-contracted with 1 pM Angiotensin II or 80 mM KCl and relaxant effects of losartan, nifedipine, 5a and...

The ion selectivity of nanopores due to the wall surface charges is capable of inducing strong coupling between fluidic and ionic motion within the system. This interaction opens up the prospect of operating nanopores as nanoscale devices for electrokinetic energy conversion. However, the very short channel lengths make the ionic movement and fluidics inside the pore to be substantially affecte...

The effect of a halo doping on SCE in PiFET is investigated. The reduction of the separation between two PiOX layers (LPiOX) followed by a local agglomeration of halo doing region makes the reverse short channel effect efficiently suppressed. As the LPiOX decreases, the subthreshold swing decreases, and the DIBL increases. The final optimized condition is LPiOX =0.7× Lg~1.0× Lg.

The field-effect mobility ~FEM! in polythiophene ~PT! polymer field-effect transistors ~PFETs! increases with reduced channel lengths during high driving forces across the source and drain, which is contradictory to the decrease in mobility caused by short-channel effects in amorphous Si thin-film transistors. The longitudinal electric-field ~across source and drain! dependence of the FE mobili...

The relationship between inflation and exchange rate in the Turkish economy is remarkable. While indirect effects of on occur through cost channel, direct emerge consumption channel. In addition, changes affect pricing decisions indexing This study examines general certain subcomponents for 2003Q1-2020Q1. For this purpose, it uses linear nonlinear ARDL models. model results, while short-term at...

We present a simple analysis showing that channel normalization techniques are less eeective when applied to spectral energies obtained by (weighted) summation of components of the short-time Fourier power spectrum of speech. We show that applying channel normalization processing prior to critical band integration or linear predictive all-pole modeling improves the eeectiveness of the techniques.

The device design of future nanoscale MOSFETs is reviewed. Major challenges in the design of the nanometer MOSFETs and the possible solutions are discussed. In this paper, special emphasis is placed on the combination of new transistor structures that suppress the short channel effect and on back-gate voltage control that suppresses the characteristics variations. Two new device architectures, ...

In this paper, we report the effect of luminous behaviour of transparent gate Recessed Channel MOSFET (RC-MOSFET).Aggressive scaling is associated with a number of higher order effects such as short channel effects, hot carrier effects and heating effect which significantly affect the device performance. The Ray trace method in MOSFET has emerged to be the ultimate solution. The proposed device...