The clinical potential of cell-based therapies is limited by poor targeting of systemically infused cells to diseased tissues [1]. In our recent study, we have developed a multi-step screening platform to identify small molecules that boost the homing properties of mesenchymal stem cells (MSCs) to sites of inflammation [2]. First, a medium-throughput screen was designed to identify small molecu...

Abstract Ecosystems around the world are at risk of critical transitions due to increasing anthropogenic pressures and climate change. Yet it is unclear where risks higher or in ecosystems more vulnerable. Here I measure resilience primary productivity proxies for marine terrestrial globally. Up 29% global ecosystem, 24% ones, show symptoms loss. These shown all biomes, but Arctic tundra boreal...

AIM To analyze the serum metabolites in patients with coronary heart disease (CHD) showing dampness syndrome and patients with chronic renal failure (CRF) showing dampness syndrome and to seek the substance that serves as the underlying basis of dampness syndrome in "same syndromes in different diseases." Methods. Metabolic spectrum by GC-MS was performed using serum samples from 29 patients wi...