Exponential crossover in Differential Evolution (DE), which is similar to 1-point crossover in genetic algorithms, continues to be used today as a default crossover operator for DE. We demonstrate that exponential crossover exploits an unnatural feature of some widely used synthetic benchmarks such as the Rosenbrock function – dependencies between adjacent variables. We show that for standard D...

While communication networks show the small-world property of short paths, the spreading dynamics in them turns out slow. Here, the time evolution of information propagation is followed through communication networks by using empirical data on contact sequences and the susceptible-infected model. Introducing null models where event sequences are appropriately shuffled, we are able to distinguis...

BACKGROUND Sister chromatid exchange (SCE) in human peripheral blood lymphocytes is one of the most extensively studied biomarkers employed to evaluate genetic damage subsequent to pesticide exposure. OBJECTIVE To estimate the pooled levels of SCE in human peripheral blood lymphocytes among population exposed to pesticide. MATERIALS AND METHODS Meta-analysis on the association between SCE f...

AIMS The aims of the present study are 1) to evaluate the free fatty acid (FFA) profile and 2) to determine the relative anaerobic and aerobic contributions to total energy consumption during repeated supramaximal cycling bouts (SCE) in adolescent boys with different body weight statuses. MATERIALS AND METHODS Normal-weight (NW), overweight (OW), and obese (OB) adolescent boys (n =15 per grou...

-The effect of the tumour promoters TPA, phenobarbitone and saccharin on the production of sister-chromatid exchanges (SCE) was studied. TPA produced a small but significant increase of SCE in Chinese hamster cell lines V-79 and CHO, and in a hybrid clone formed by fusion of CHO with rat liver epithelial cells. The enhancement of SCE by TPA was not affected by the type of culture medium, heatin...

The aim of this study was to evaluate the immunomodulatory effects of sugar cane extract (SCE) on the biological activities of neutrophils in mice. Six-week-old BALB/c mice were fed 1250 mg/kg of SCE once. The generation, migration and biological functions of neutrophils and the survival rates of the mice in response to Salmonella typhimurium infection were evaluated. The results show that the ...

Diaziquone (AZQ) (NSC 182986), a lipid-soluble benzoquinone deriv ative, is presently being tested in a Phase III clinical trial to determine its efficacy in patients with anaplastic gliomas compared to the more standard l,3-bis(2-chloroethyl)-l-nitrosoiirea (BCNU) treatment follow ing whole-brain irradiation. These patients on single-drug chemotherapy allowed us to evaluate the effects of each...

Chromosome ends are known hotspots of meiotic recombination and double-strand breaks. We monitored mitotic sister chromatid exchange (SCE) in telomeres and subtelomeres and found that 17% of all SCE occurs in the terminal 0.1% of the chromosome. Telomeres and subtelomeres are significantly enriched for SCEs, exhibiting rates of SCE per basepair that are at least 1,600 and 160 times greater, res...

The aim of the present study was to develop and standardize a cytogenetic approach for evaluation of the mutagenic potential of chemicals that induce cell cycle arrest in the G2 phase. Even though cytogenetic end-points such as sister chromatid exchange (SCE) have been extensively used to indirectly assess the DNA-damaging potential of various chemicals, they are based on metaphase chromosome a...