Other SectionsAbstractIntroductionDNA Damage Responding GenesDNA Repairing GenesGrowth Signaling GenesConclusionConflict of interestAcknowledgementsFigureReference

Abstract Background Intramuscular fat (IMF) content is a vital parameter for assessing pork quality. Increasing evidence has shown that microRNAs (miRNAs) play an important role in regulating porcine IMF deposition. Here, novel miRNA implicated adipogenesis was found, and its effect regulatory mechanism were further explored with respect to intramuscular preadipocyte proliferation differentiati...

it has been suggested that single nucleotide polymorphisms (snps) in genes involved in toll-like receptors (tlrs) pathway may exhibit broad effects on function of this network and might contribute to a range of human diseases. however, the extent to which these variations affect tlr signaling is not well understood. in this study, we adopted a bioinformatics approach to predict the consequences...

The signaling pathways regulated by mitochondria involve among others, the intrinsic apoptotic pathway, calcium homeostasis and reactive oxygen species signaling, ATP synthesis. aim of this review is to narrate importance flavanoids (e.g., flavones, flavonols, flavonols-3-ols, anthocyanidins isoflavones) in mitochondrial biogenesis. Therefore, induction biogenesis can be stimulated nutrition st...

Hydrogen sulfide (H2S) has a variety of physiological functions. H2S reportedly increases intracellular Ca2+ concentration ([Ca2+]i) in astrocytes. However, the precise mechanism and functional role this increase are not known. Here, we examined effects on [Ca2+]i astrocytes from rat spinal cord whether affects ATP-induced signaling, which is known to be involved synaptic function. Na2S (150 ?M...

The elaborate redox network of the cell, comprising events like turnover reactive oxygen species (ROS), sensing, signaling, expression redox-sensitive genes, etc., often orchestrates with other bonafide hormonal signaling pathways through their synergistic or antagonistic action in plant cell. cue generated cells under fluctuating environmental conditions can significantly influence biosyntheti...

The melanocortin 1 receptor (MC1R) is a G-protein coupled (GPCR) which plays major role in controlling melanogenesis. A large body of evidence indicates that GPCRs are part protein complexes critical for their signal transduction properties. Among proteins may affect MC1R signaling, neurofibromin (Nf1), GTPase activating (GAP) Ras, special interest as it regulates adenylyl cyclase activity and ...

Basal cell carcinoma (BCC) is driven by constitutive activation of the Hedgehog (Hh) signaling pathway, most commonly through loss-of-function mutations in PTCH1. Using animal models, we demonstrate here that microscopic BCC-like tumors initiated loss Ptch1 or gain Smo fail to progress and eventually enter into a dormant state. Because NOTCH1/2 TRP53 are detected human BCC, sought determine if ...