activation of cannabinoid receptors, which are present in brain, heart, blood vessels, spleen and immune system (1,2). Cannabis increases sympathetic activity while decreasing parasympathetic activity, producing tachycardia and increased myocardial contractility (4-6). Additionally, smoked cannabis is associated with an increase in carboxyhemoglobin, resulting in decreased oxygen-carrying capac...

Sildenafil citrate is one of the most effective agents for treatment of erectile dysfunction which acts by inhibiting the cGMP-specific phosphodiesterase type 5. Extensive research work is focused on flash release dosage forms and especially fast dissolving films are successful to attract pharma-industry due to ease of preparation and opportunity to extend patent life. Films are widely acceptab...

Pulmonary hypertension refers to a group of diseases that is characterised by high pressure in the pulmonary artery, and pulmonary vascular resistance. Persistent pulmonary hypertension in the newborn is a condition in which the pulmonary artery pressure does not decrease after birth. It may occur in as many as 6.8 in 1 000 live births. Phosphodiesterase type 5 (PDE5) is the predominant phospho...