BACKGROUND Defects in endoplasmic reticulum homeostasis are common occurrences in different diseases, such as diabetes, in which the function of endoplasmic reticulum is disrupted. It is now well established that ion channels of endoplasmic reticulum membrane have a critical role in endoplasmic reticulum luminal homeostasis. Our previous studies showed the presence of an ATP-sensitive cationic ...

Single channel currents through Ca2+-activated K+ channels of bovine chromaffin cells were measured to determine the effects of small ions on permeation through the channel. The channel selects strongly for K+ over Na+ and Cs+, and Rb+ carries a smaller current through the channel than K+. Tetraethylammonium ion (TEA+) blocks channel currents when applied to either side of the membrane; it is e...

The channel of the viral DNA packaging motor allows dsDNA to enter the protein procapsid shell during maturation and to exit during infection. We recently showed that the bacteriophage phi29 DNA packaging motor exercises a one-way traffic property using a channel as a valve for dsDNA translocation. This raises a question of how dsDNA is ejected during infection if the channel only allows the ds...

Objective: Spiking activity of individual neurons can be separated from the acquired multi-unit with spike sorting methods. Processing recorded high-dimensional neural data take a large amount time when performed on general-purpose computers. Methods: In this paper, an FPGA-based real-time system is presented which takes into account spatial correlation between electrical signals closely-packed...

This paper considers the use of the best high-rate k/(k+1) convolutional codes obtained using the new construction technique described in [1] in a concatenated scheme. Simulation results for an AWGN channel and for a realistic magnetic recording channel are reported. It is shown that these codes, endowed with a decoding algorithm working on the dual code, yield performance improvements over the...

Prokaryotic channels, such as Erwinia chrysanthemi ligand-gated ion channel (ELIC) and Gloeobacter violaceus ligand-gated ion channel, give key structural information for the pentameric ligand-gated ion channel family, which includes nicotinic acetylcholine receptors. ELIC, a cationic channel from E. chrysanthemi, is particularly suitable for single-channel recording because of its high conduct...

OBJECTIVE Micro-electrocorticography (μECoG) offers a minimally invasive neural interface with high spatial resolution over large areas of cortex. However, electrode arrays with many contacts that are individually wired to external recording systems are cumbersome and make recordings in freely behaving rodents challenging. We report a novel high-density 60-electrode system for μECoG recording i...

This paper proposes a novel technique for separating single channel recording of speech mixture using a hybrid of maximum likelihood and maximum a posteriori estimators. In addition, the new algorithm proposes a new approach that accounts for the time structure of the source signals by encoding them into a set of basis filters that are characteristically the most significant. Real time testing ...

Fourier incoherent single channel holography (FISCH) is a method for recording spatially incoherent digital Fourier holograms. We present a general design of enhanced FISCH with a smaller optical path difference between interfering beams, when compared to our initial design [Opt. Lett. 37, 3723 (2012)]. This reduction enables a proper system operation with a wider bandwidth. Potential resolutio...