It has been known that a combination of multiple kernels and addition of various resources are the best options for improving effectiveness of kernel-based PPI extraction methods. These supplements, however, involve extensive kernel adaptation and feature selection processes, which attenuate the original benefits of the kernel methods. This paper shows that we are able to achieve the best perfo...

Models obtained by decision tree induction techniques excel in being interpretable. However, they can be prone to overfitting, which results in a low predictive performance. Ensemble techniques are able to achieve a higher accuracy. However, this comes at a cost of losing interpretability of the resulting model. This makes ensemble techniques impractical in applications where decision support, ...

Extracting kinetic models from single molecule data is an important route to mechanistic insight in biophysics, chemistry, and biology. Data collected from force spectroscopy can probe discrete hops of a single molecule between different conformational states. Model extraction from such data is a challenging inverse problem because single molecule data are noisy and rich in structure. Standard ...

Single drop micro extraction (SDME) has emerged over the last 10–15 years as one of the simplest and most easily implemented forms of micro-scale sample cleanup and preconcentration. In the most common arrangement, an ordinary chromatography syringe is used to suspend micro liter quantities of extracting solvent either directly immersed in the sample, or in the headspace above the sample. The s...

As one of the key steps in the feature extraction of targets consisting of both trihedral and dihedral corner re ectors via synthetic aperture radar, this paper studies the problem of estimating the parameters of a single dihedral corner re ector. The data model of the problem and the Cram er-Rao bounds (CRBs) for the parameter estimates of the data model are presented. Two algorithms, the FFTB...

We investigate the atomistic details of a single atom-extraction process realized by using the scanning tunneling microscope tip-cluster interaction on a Ag(111) surface at 6 K. Single atoms are extracted from a silver cluster one atom at a time using small tunneling biases less than 35 mV. Combined total energy calculations and molecular dynamics simulations show a lowering of the atom-extract...