نتایج جستجو برای: skeletal cell
تعداد نتایج: 1763604 فیلتر نتایج به سال:
Parathyroid hormone-related peptide (PTHrP) appears to play a major role in skeletal development. Targeted disruption of the PTHrP gene in mice causes skeletal dysplasia with accelerated chondrocyte maturation (Amizuka, N., H. Warshawsky, J.E. Henderson, D. Goltzman, and A.C. Karaplis. 1994. J. Cell Biol. 126:1611-1623; Karaplis, A.C., A. Luz, J. Glowacki, R.T. Bronson, V.L.J. Tybulewicz, H.M. ...
Skeletal metastases are frequent complications of many cancers, causing bone (fractures, pain, disability) that negatively affect the patient’s quality life. Here, we first discuss burden skeletal in cancer metastasis. We then describe pathophysiology Bone metastasis is a multistage process: long before development clinically detectable metastases, circulating tumor cells settle and enter dorma...
Skeletal muscle satellite cells are considered to play a crucial role in muscle fiber maintenance, repair and remodeling. Our knowledge of the role of satellite cells in muscle fiber adaptation has traditionally relied on in vitro cell and in vivo animal models. Over the past decade, a genuine effort has been made to translate these results to humans under physiological conditions. Findings fro...
Cardiomyoplasty with skeletal myoblasts may benefit cardiac function after infarction. Recent reports indicate that adult stem cells can fuse with other cell types. Because myoblasts are "fusigenic" cells by nature, we hypothesized they might be particularly likely to fuse with cardiomyocytes. To test this, neonatal rat cardiomyocytes labeled with LacZ and green fluorescent protein (GFP) were c...
Extensive analyses of mice carrying null mutations in paired box 7 (Pax7) have confirmed the progressive loss of the satellite cell lineage in skeletal muscle, resulting in severe muscle atrophy and death. A recent study using floxed alleles and tamoxifen-induced inactivation concluded that after 3 wk of age, Pax7 was entirely dispensable for satellite cell function. Here, we demonstrate that P...
The regulation of myogenic progenitor cells during muscle regeneration is not clearly understood. We have previously shown that the Foxk1 gene, a member of the forkhead/winged helix family of transcription factors, is expressed in myogenic progenitor cells in adult skeletal muscle. In the present study, we utilize transgenic technology and demonstrate that the 4.6 kb upstream fragment of the Fo...
Skeletal muscle regeneration mainly depends on satellite cells, a population of resident muscle stem cells. However, our understanding of the molecular mechanisms underlying satellite cell activation is still largely undefined. Here, we show that Cripto, a regulator of early embryogenesis, is a novel regulator of muscle regeneration and satellite cell progression toward the myogenic lineage. Co...
McGrath, Meagan J., Christina A. Mitchell, Imogen D. Coghill, Paul A. Robinson, and Susan Brown. Skeletal muscle LIM protein 1 (SLIM1/FHL1) induces 5 1-integrin-dependent myocyte elongation. Am J Physiol Cell Physiol 285: C1513–C1526, 2003. First published August 13, 2003; 10.1152/ajpcell.00207.2003.—Skeletal muscle LIM protein 1 (SLIM1/FHL1) contains four and a half LIM domains and is highly e...
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