A new spectrophotometric method is proposed for the assay of ranitidine hydrochloride (RNH) in bulk drug and in its dosage forms using ceric ammonium sulphate (CAS) and two dyes, malachite (MAG) green and crystal violet (CV) as reagents. The method involves the addition of a known excess of ceric ammonium sulphate to ranitidine hydrochloride in acid medium, followed by the determination of unre...

Objective: Tapentadol Hydrochloride was approved (November 2008) by the United States Food and Drug Administration for relief of moderate to severe pain. It is an opioid analgesic, acts dual mechanism as receptor agonist norepinephrine reuptake inhibitor. The present research work aimed develop accurate, precise, rapid RP-HPLC method subsequently validates according International Conference on ...

OBJECTIVES To characterize the uptake, washout, and metabolism of lidocaine hydrochloride in the iris/ciliary body and cornea. METHODS Iris/ciliary body uptake of lidocaine hydrochloride was measured by incubating human and rabbit irides in radiolabeled carbon 14-1% lidocaine hydrochloride for 2 to 60 minutes. Washout was determined by incubating the iris in 14C-1% lidocaine hydrochloride for...

A floating type of dosage form of ranitidine hydrochloride in the form of microspheres capable of floating on simulated gastric fluid was prepared by solvent evaporation technique. Microspheres prepared with ethyl cellulose, Eudragit(®) RS100 alone or in combination were evaluated for percent yield, drug entrapment, percent buoyancy and drug release and the results demonstrated satisfactory per...

Two simple, precise and economical UV methods have been developed for the simultaneous estimation of Sitagliptinphosphate Metformin hydrochloride in bulk pharmaceutical dosage form. Method A is Absorbance maximamethod,whichisbasedonmeasurementofabsorptionatmaximumwavelengthof266nmand232nmforSitagliptinphosphateandMetforminhydrochloriderespectively.MethodBisareaundercurve(AUC),inthewavelength ra...

InnoPran XL (propranolol hydrochloride) is a nonselective, beta-adrenergic receptorblocking agent for oral administration, available as an extended release product. InnoPran XL is available as 80 mg and 120 mg capsules which contain sustained-release beads. Each of the beads contains propranolol hydrochloride and is coated with dual membranes. These membranes are designed to retard release of p...

Sir,?In reply to Capt. T. D. W. Gillespie's inquiry in the Novtmber issue of the I. M. Q. as to the quantity of quinine urea hydrochloride to be injected hypodermically to produce local anaesthesia, I may say as follows: In the New York Medical Journal (1915, II, 708) Amster recommends quin-urea hydro as a local anaesthetic. He has performed 200 severe operations with a freshly prepared solutio...

Young albino rats (120-190 g) were divided in 4 groups (6 animals per group). One group was injected with clonidine hydrochloride (100 ",g/kg. ip); another group received equivalent volume of normal saline only. The third group also received clonidine but was given phenoxybenzamine hydrochloride (10 mg/kg. ip) 1 hr before clonidine Injection. The fourth group received phenoxybenzamine hydrochlo...

BACKGROUND AND THE PURPOSE OF THE STUDY The binding ability of a drug to serum albumin has influence on the pharmacokinetics of a drug. In the present study, the mutual interaction of anticancer drug erlotinib hydrochloride with bovine serum albumin (BSA) using fluorescence and UV/vis spectroscopy was investigated. METHODS The BSA solution (0.1 mM) was prepared daily in Tris buffer (0.05 mol ...