نتایج جستجو برای: skin cytotoxicity
تعداد نتایج: 237264 فیلتر نتایج به سال:
Phenylethyl resorcinol (PR) is a potent tyrosinase inhibitor and cosmeceutical skin lightening agent. However, the application of PR limited by photoinstability poor solubility. In this study, we formulated optimized phenylethyl loaded nanoliposomes (PR-NLPs) to improve stability effective delivery PR. PR-NLPs were prepared ethanol injection method single factor experimental Box–Behnken design....
Ultraviolet-B irradiation is a common environmental stressor that has detrimental effects on human skin. Natural sunscreens are well-known for their ability to benefit inflamed sunburn and dry This study examined the effect of formulated Ipomoea carnea herbal cream UVB-induced skin damage. We screened bioactive compounds I. crude extract, showing significant antioxidant. Additionally, we evalua...
Aesculus hippocastanum L., also known as horse chestnut, is an ornamental tree whose seeds are mostly discarded in landfills the regions where they grown. However, recent studies have shown that these can be a source of interesting compounds for several industries. This work aimed to chemically characterize chestnut at level recognized their wide bioactivity, i.e., organic acids, including phen...
Psoriasis is a refractory and difficult-to-treat skin disorder. Neutrophil-targeting approach represents promising option for psoriasis therapy. This study developed examined NIMP-R14-conjugated immunonanoparticles specific targeting to neutrophils associated with psoriasiform dermatitis. In the process, roflumilast (RFL), as phosphodiesterase (PDE) 4 inhibitor, was encapsulated into nanocarrie...
BACKGROUND The propensity of compounds to produce adverse health effects in humans is generally evaluated using animal-based test methods. Such methods can be relatively expensive, low-throughput, and associated with pain suffered by the treated animals. In addition, differences in species biology may confound extrapolation to human health effects. OBJECTIVE The National Toxicology Program an...
This study aims to characterize and evaluate the applicability of Polyhedral OligomericSilsesquioxane (POSS)/ Poly (carbonate-urea) Urethane (PCU) nanocomposite films as a temporary skin substitute by means of FTIR, MTT assay, cell proliferation assay and SEM studies. FTIR spectra showed all the characteristic peaks of POSS/PCU nanocomposite. The indirect cytotoxicity of membranes was investig...
In this study the role of glutathione (GSH) in sulfur mustard -induced oxidative stress and cytotoxicity, in human skin fibroblast cell line (HF2FF) was evaluated. Sulfur mustard-induced superoxide radical and hydrogen peroxide formation were evaluated by determination of superoxide dismutase and catalase activity in cell lysate. The cytotoxicity of sulfur mustard was estimated by lactate dehyd...
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