Disclosures: G W Blunn (5), Roberta Ferro Godoy (N), Hannah Wilson (3A Zimmer Biomet), Imran Khan (3A Zimmer Biomet), M J Coathup (N) INTRODUCTION: Data from the National Joint Registry of England and Wales (NJR) has shown that hip replacements with metal-onmetal (MoM) bearings, have significantly higher revision rates compared to metal-on-polyethylene (MoP). According to the NJR approximately ...

The absorption, distribution, metabolism and excretion (ADME) of metabolites and toxic organic solutes are orchestrated by the ATP-binding cassette (ABC) transporters and the organic solute carrier family (SLC) proteins. A large number of ABC and SLC transpoters exist; however, only a small number have been well characterized. To facilitate the analysis of these transporters, which is important...

Background We investigated the clinical relevance of SLC 19A1 genetic variability for high dose methotrexate (HD-MTX) related toxicities in children and adolescents with acute lymphoblastic leukaemia (ALL) and non Hodgkin malignant lymphoma (NHML). Patients and methods Eighty-eight children and adolescents with ALL/NHML were investigated for the influence of SLC 19A1 single nucleotide polymor...

Pairs of forward and reverse primers and TaqMan probes specific to each of 173 human solute carrier (SLC) transporters were prepared. The mRNA expression level of each target transporter was analyzed in total RNA from single and pooled specimens of various human tissues (adrenal gland, bladder, bone marrow, brain, colon, heart, kidney, liver, lung, mammary gland, ovary, pancreas, peripheral leu...

With enough luminosity, the SLC could contribute to most of the high energy physics of current interest such as new hadrons, quark molecules, glueballs and studies of the Standard Model and Minimal Supersymmetric SM in the form of particle searches for the lowest mass Higgs or selectron or tests of the point-like predictions for theW;Z or ~ eR. Some experiments require alternative incident chan...

A low intensity electron beam parasitic to the operation of the Stanford Linear Collider (SLC) has been transported through the Final Focus Test Beam (FFTB) facility making secondary test beams available for users. Photons generated in collimation of the SLC electron and positron beams in the linac pass through a splitter magnet that deflects the primary beams away from the linac axis into the ...

We prove the abundance conjecture for projective slc surfaces over arbitrary fields of positive characteristic. The proof relies on lc abritrary fields, proved by Tanaka, and technique Hacon Xu to descend semi-ampleness from normalization. also present applications dlt threefold pairs, mixed characteristic families surfaces.