Psychological stress has been shown to trigger systemic lupus erythematosus (SLE). However, objective evidence of symptom aggravation due to mental stress is difficult to identify. We aimed to investigate the relationship between SLE disease activity and mental stress, and the usefulness of saliva as an assessment index for stress in patients with SLE. We prospectively assessed the salivary str...

background: the aim of the present study was to determine the prevalence and prognosis of cerebrovascular accident(cva) and its subtypes among iranian patients with systemic lupus erythematosus (sle). methods: in a cross-sectional study, medical records of 575 sle patients were reviewed. the patients developing cva in their course of disease were extracted. in these patients, data about demogra...

Abstract Background The prevalence of primary headache in patients with systemic lupus erythematosus (SLE) varies widely and whether it should be attributed to neurological involvement is controversial. We aimed investigate the characteristics SLE patients, describe its association disease-related variables brain imaging, explore impact on life. Results overall was 54.4%, migraine most common t...

BACKGROUND Systemic Lupus Erythematosus (SLE) is a complex chronic immunological disease characterized by increased B cell activity and altered T cell function. OBJECTIVE To investigate relationship between T lymphocyte subsets and cortisol with the disease activity of systemic lupus erythematosus patients in North India. MATERIALS AND METHODS The percentage of CD4(+) and CD8(+) T cells in ...

INTRODUCTION Progranulin (PGRN) is the precursor of granulin (GRN), a soluble cofactor for toll-like receptor 9 (TLR9) signaling evoked by oligonucleotide (CpG)-DNA. Because TLR9 signaling plays an important role in systemic lupus erythematosus (SLE), we investigated whether PGRN is involved in the pathogenesis of SLE. METHODS We measured concentrations of serum PGRN and interleukin-6 (IL-6) ...

INTRODUCTION Systemic lupus erythematosus (SLE) is an autoimmune disease, with higher prevalence in women. An incidence peak occurs during the reproductive years, suggesting that estradiol may play a role in the clinical presentation of SLE. Anticardiolipin antibodies (ACA) are associated with antiphospholipid antibody syndrome (APLS), but can be found in patients with SLE without APLS, and rel...

BACKGROUND To determine whether optimal use of serial measurements of serum levels of soluble cell adhesion molecules (CAM) can improve monitoring of disease activity in SLE. METHODS Serum levels of soluble CAM and conventional SLE biomarkers were measured in serial samples (n = 80) from 21 SLE patients during and after flare and correlated in longitudinal analysis with disease activity deter...

Results: Positive serum ADA was found in 38 patients with JIA (38.9%), 9 patients (52.9%) with SLE and 6 patients (20%) with HSP. During the disease activity (before treatment), the mean serum ADA in patients with JRA was 15.1±10.9 IU/l, vs. 12.6±4.5 IU/l in patients with HSP and 18.8±11.95 IU/l in patients with SLE (P=0.097). There was no significant differences in changes of ADA levels betwee...

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by heterogeneous clinical manifestations involving virtually the entire body. The pain in SLE can have different causes. The SLE classification criteria include mainly the musculoskeletal manifestations of pain, which are commonly reported as initial symptoms of SLE, such as arthralgia, arthritis and/or myalgia. Chronic w...

INTRODUCTION Semaphorin 3A (sema3A) and neuropilin-1 (NP-1) play a regulatory role in immune responses and have a demonstrated effect on the course of collagen induced arthritis. This study was undertaken to evaluate the role of sema3A and NP-1 in the pathogenesis of systemic lupus erythematosus (SLE) and the specific effect of sema3A on the auto-reactive properties of B cells in SLE patients. ...