نتایج جستجو برای: sma

تعداد نتایج: 18948  

2004
Mohammad H Elahinia Mehdi Ahmadian Hashem Ashrafiuon

Measuring the state variables of systems actuated by shape memory alloys (SMAs) is normally a difficult task because of the small diameter of the SMA wires. In such cases, as an alternative, observers are used to estimate the state vector. This paper presents an extended Kalman filter (EKF) for estimation of the state variables of a single-degree-of-freedom rotary manipulator actuated by an SMA...

2008
Gerard Elberg Lijuan Chen Dorit Elberg Michael D. Chan Charlotte J. Logan Martin A. Turman

Elberg G, Chen L, Elberg D, Chan MD, Logan CJ, Turman MA. MKL1 mediates TGF1-induced -smooth muscle actin expression in human renal epithelial cells. Am J Physiol Renal Physiol 294: F1116–F1128, 2008. First published March 12, 2008; doi:10.1152/ajprenal.00142.2007.—Transforming growth factor1 (TGF1) is known to induce epithelial-mesenchymal transition in the kidney, a process involved in tubulo...

خاصیت بازگشت‌پذیری آلیاژهای هوشمند حافظه‌دار (SMAهای) فوق الاستیک، ویژگی منحصر ‌به فردی است که از آن می‌توان در ساخت و تقویت اجزای بتن مسلح استفاده کرد. اجزای بتنی تقویت شده با این آلیاژها، قابلیت شکل‌پذیری و جذب انرژی بالاتری نسبت به تیرهای بتن مسلح معمولی دارند و هم‌چنین در چرخه‌های متوالی بارگذاری و باربرداری، خسارت کم‌تری نسبت به تیرهای بتن مسلح رایج متحمل می‌شوند. هدف از پژوهش پیش رو، بررس...

Journal: :Respiratory Research 2007
Zhuang Wu Leilei Yang Lin Cai Min Zhang Xuan Cheng Xiao Yang Jun Xu

BACKGROUND Epithelial to mesenchymal transition (EMT) in alveolar epithelial cells (AECs) has been widely observed in patients suffering interstitial pulmonary fibrosis. In vitro studies have also demonstrated that AECs could convert into myofibroblasts following exposure to TGF-beta1. In this study, we examined whether EMT occurs in bleomycin (BLM) induced pulmonary fibrosis, and the involveme...

Journal: :Journal of clinical pathology 2003
H Chauhan A Abraham J R A Phillips J H Pringle R A Walker J L Jones

AIMS Smooth muscle actin (SMA) positive myofibroblasts have been implicated in tumour invasion; however, acquisition of SMA is not limited to peritumorous fibroblasts and other changes in fibroblasts may be more specifically related to the malignant environment. CD34 is a sialomucin expressed by normal breast fibroblasts but lost in invasive carcinomas. The aim of this study was to establish th...

2017
Danielle Ramsey Mariacristina Scoto Anna Mayhew Marion Main Elena S Mazzone Jacqueline Montes Roberto de Sanctis Sally Dunaway Young Rachel Salazar Allan M Glanzman Amy Pasternak Janet Quigley Elizabeth Mirek Tina Duong Richard Gee Matthew Civitello Gihan Tennekoon Marika Pane Maria Carmela Pera Kate Bushby John Day Basil T Darras Darryl De Vivo Richard Finkel Eugenio Mercuri Francesco Muntoni

Recent translational research developments in Spinal Muscular Atrophy (SMA), outcome measure design and demands from regulatory authorities require that clinical outcome assessments are 'fit for purpose'. An international collaboration (SMA REACH UK, Italian SMA Network and PNCRN USA) undertook an iterative process to address discontinuity in the recorded performance of the Hammersmith Function...

Journal: :Human molecular genetics 2011
Marta Bosch-Marcé Claribel D Wee Tara L Martinez Celeste E Lipkes Dong W Choe Lingling Kong James P Van Meerbeke Antonio Musarò Charlotte J Sumner

Spinal muscular atrophy (SMA) is an inherited motor neuron disease caused by the mutation of the survival motor neuron 1 (SMN1) gene and deficiency of the SMN protein. Severe SMA mice have abnormal motor function and small, immature myofibers early in development suggesting that SMN protein deficiency results in retarded muscle growth. Insulin-like growth factor 1 (IGF-1) stimulates myoblast pr...

Journal: :Paediatric anaesthesia 2013
Gunilla Islander

UNLABELLED Spinal muscle atrophy (SMA) is autosomal recessive and one of the most common inherited lethal diseases in childhood. The spectrum of symptoms of SMA is continuous and varies from neonatal death to progressive symmetrical muscle weakness first appearing in adulthood. The disease is produced by degeneration of spinal motor neurons and can be described in three or more categories: SMA ...

2016
Eva Szunyogova Haiyan Zhou Gillian K. Maxwell Rachael A. Powis Muntoni Francesco Thomas H. Gillingwater Simon H. Parson

Spinal Muscular Atrophy (SMA) is caused by mutation or deletion of the survival motor neuron 1 (SMN1) gene. Decreased levels of, cell-ubiquitous, SMN protein is associated with a range of systemic pathologies reported in severe patients. Despite high levels of SMN protein in normal liver, there is no comprehensive study of liver pathology in SMA. We describe failed liver development in response...

2017
Shuyong Jiang Dong Sun Yanqiu Zhang Li Hu

Deformation behavior and microstructure evolution of NiTiCu shape memory alloy (SMA), which possesses martensite phase at room temperature, were investigated based on a uniaxial compression test at the temperatures of 700~1000 ◦C and at the strain rates of 0.0005~0.5 s−1. The constitutive equation of NiTiCu SMA was established in order to describe the flow characteristic of NiTiCu SMA, which is...

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