The aim of the study was to determine if prematurely born children who had suffered intra-uterine growth retardation (IUGR) had more severe lung function abnormalities than those born an appropriate weight for gestational age (AGA). Analysis of the lung function results of 119 infants (median (range) gestational age of 30 (23-35) weeks) was undertaken. In total, 31 of the infants had suffered I...

One in five pregnant women suffer from gestational complications, prevalently driven by placental malfunction. Using RNASeq, we analyzed differential placental gene expression in cases of normal gestation, late-onset preeclampsia (LO-PE), gestational diabetes (GD) and pregnancies ending with the birth of small-for-gestational-age (SGA) or large-for-gestational-age (LGA) newborns (n = 8/group). ...

Intra Uterine Growth Retardation (IUGR) refers to insufficient fetal growth diagnosed either by two direct intrauterine growth assessment (ultra-sonography) or when the fetus or newborn length (height) is less than two standard deviations (or third percentile) below the mean for gestational age (NIKLASSON et. al. 1991; DE ZEGLER 1997). When the fetus or newborn body size (wight or length) is in...

OBJECTIVE Fetuses conceived by assisted reproductive technology (ART) and those that are small-for-gestational age (SGA) show cardiovascular remodeling in utero; however, these two conditions are often associated. We aimed to evaluate the differential effect of ART and SGA on fetal cardiac remodeling. METHODS This was a prospective cohort study of term singleton pregnancies seen at our depart...

BACKGROUND The ophthalmic artery Doppler waveform (OADW) is thought to correlate with severity of systemic atherosclerosis. The goal of the present study was to evaluate risk of cardiovascular disease (CVD) in newborns small for gestational age (SGA) and appropriate for gestational age (AGA). METHODS AND RESULTS A total of 15 SGA and 26 AGA newborns were enrolled in the study. OADW was compar...

OBJECTIVE Delayed passage of stool is a result of both gestational immaturity and illness severity. Small for gestational age (SGA) preterm infants are at high risk of gastrointestinal (GI) complications. We aimed to analyse the effects of a strict nutrition and stool protocol on GI problems in SGA compared to appropriate for gestational age (AGA) preterm infants. METHODS Retrospective cohort...

Objective  The retroviral genes encoding Syncytin-1 ( SYN1 ) and Syncytin-2 ( SYN2 ) are epigenetically regulated, uniquely expressed in the placenta and critical to placental function. We sought to determine if placental expression and methylation patterns of SYN1 and SYN2 from pregnancies complicated by fetal growth restriction (FGR) differed from physiologic small for gestational age (SGA) a...