The development of intestinal cancer involves complex genetic and epigenetic alterations in the intestinal mucosa. The principal signaling pathway responsible for the initiation of tumor formation, the APC– catenin–TCF4 pathway, regulates both cell proliferation and colonic cell differentiation, but many other intrinsic and extrinsic signals also modulate these cell maturation pathways. The cha...

Studies have indicated that platelets play an important role in tumorigenesis, and an abundance of platelets accumulate in the ovarian tumor microenvironment outside the vasculature. However, whether cancer cells recruit platelets within intestinal tumors and how they signal adherent platelets to enter intestinal tumor tissues remain unknown. Here, we unexpectedly found that large numbers of pl...

BACKGROUND/AIMS Ethanol administration causes intestinal epithelial cell damage by increasing intestinal permeability and the translocation of endotoxins from intestinal bacterial flora. Heat shock proteins (HSPs) are associated with recovery and protection from cell damage. The aim of the current study was to investigate differences in the expression of HSPs in the small intestine and the bioc...

gastric bezoars are gastric masses, which rarely cause intestinal obstruction by passing through the small bowel. in this article, we report a 56 year-old man with no history of gastric surgery who presented with intestinal obstruction. the obstruction seemed to be in terminal ileum. colonoscopy was done and a movable mass was noted, which was extracted from the cecum by colonoscope resulting i...

Multiple intestinal neoplasia (Min) mice were originally identified by Moser et al. Min mice have a heterozygous mutation in the tumor suppressor gene, adenomatous polyposis coli (Apc). The APC gene is mutated in familial adenomatous polyposis (FAP). Min mice spontaneously develop intestinal polyps, similar to humans, but mainly in the small intestine. Polyps form as early as approximately 4 we...

The objective of the study was to demonstrate difficulties diagnosing neuroendocrine tumor (NET) small intestine at example a concrete clinical case. In case presented, manifestations disease were nonspecific and examination began from low-informative method multispiral computed tomography (MSCT) without bolus contrast that reason wrong diagnosis for 7 months. detection swollen lymph node in me...

Interdigitating Dendritic Cell Sarcoma (IDCS) is an infrequent dendritic cell tumor which mainly affects the lymphatic system. Intestinal metastasis from uterine IDCS is extremely rare. Here we report a case of a 76-year-old female presenting with vaginal bleeding and acute abdomen. The final diagnosis revealed a small bowel perforation due to metastatic involvement from uterine cervix IDCS. In...