Dear Editor, The recent article by Mohammadzadeh et al.[1] on the latest issue of this Journal showed that the T allele +276G/T SNP of ADIPOQ gene is more associated with the increasing risk of coronary artery disease (CAD) in subjects with type 2 diabetes. Adipocytes were described in myocardial tissue of CAD patients and their role recently discussed[2,3]. Susceptibility to CAD by polymorp...

The objective of the present study was to assess the frequency distribution of markers in the diacylglycerol acyltransferase (DGAT1), fatty acid binding protein 4 (FABP4), leptin (LEP), retinoic acid receptor-related orphan receptor C (RORC), and stearoyl-CoA desaturase (SCD1) genes in a Spanish commercial crossbred population (n = 286) produced in southwest Spain. We have also evaluated the as...

Assessing interspecific adaptive genetic variation across environmental gradients offers insight into the scale of habitat-dependent heritable heterotic effects, which may ultimately enable pre-breeding for abiotic stress tolerance and novel climates. However, environmentally dependent allelic effects are often bypassed by intra-specific single-locality genome-wide associations studies (GWAS). ...

Recent advances in next-generation sequencing (NGS) and single nucleotide polymorphism (SNP) genotyping promise to greatly accelerate crop improvement if properly deployed. High-throughput SNP genotyping offers a number of advantages over previous marker systems, including an abundance of markers, rapid processing of large populations, a variety of genotyping systems to meet different needs, an...

High-density SNP arrays for genome-wide assessment of allelic variation have made high resolution genetic characterization of crop germplasm feasible. A medium density array for apple, the IRSC 8K SNP array, has been successfully developed and used for screens of bi-parental populations. However, the number of robust and well-distributed markers contained on this array was not sufficient to per...

BACKGROUND To date, common genetic variants in approximately 70 loci have been identified for breast cancer via genome-wide association studies (GWAS). It is unknown whether rare variants in these loci are also associated with breast cancer risk. METHODS We investigated rare missense/nonsense variants with minor allele frequency (MAF) ≤5% located in flanking 500 kb of each of the index single...

Reproductive efficiency is of economic importance in commercial beef cattle production, as failure to achieve pregnancy reduces the number of calves marketed per cow exposed. Identification of genetic markers with predictive merit for reproductive success would facilitate early selection of sires with daughters having improved reproductive rate without increasing generation intervals. To identi...

An efficient hybrid breeding program defines and utilizes a few heterotic groups. Objectives of this study were to determine genetic diversity alignment South Africa maize inbred lines collection towards tropical temperate testers. Forty-four genotyped with 56,110 single nucleotide polymorphism (SNP) markers. A total 40 crossed two line Due seed shortages, testcross hybrids containing 14 18 use...

During the last few decades, the use of molecular markers, revealing polymorphism at the DNA level, has been playing an increasing part in plant biotechnology and their genetics studies. There are different types of markers viz. morphological, biochemical and DNA based molecular markers. These DNA based markers are differentiates in two types first non PCR based (RFLP) and second is PCR based m...

Alzheimer’s disease (AD) is the main cause of dementia worldwide, and genetic mechanism which not yet fully understood. Much evidence has accumulated over past decade to suggest that after first large-scale genome-wide association studies (GWAS) were conducted, problem “missing heritability” in AD still a great challenge. Epistasis been considered as one causes AD, largely ignored human genetic...