Antonakos for the PEAR apathy project. Their great work helped this dissertation generate rigorous and fruitful findings. I also want to thank two NIH/NINR-funded studies— " Wandering: Background and Proximal Factors " (PI: Algase) and " Bioburden Predictors of Diabetic Ulcer Complications " (PI: Gardner)—for providing access to research samples and resources. I am extremely grateful for my dis...

BACKGROUND Apathy in DM1 has long been acknowledged in clinical practice. However, a major drawback is that the concept has been only sparsely explored in previous specific studies. This study aimed to determine the prevalence of apathy in myotonic dystrophy (DM1), to compare it with facioscapulohumeral dystrophy (FSHD) patients and normal healthy controls, and explore its relationship to psych...

THE LANCET Neurology Vol 1 June 2002 http://neurology.thelancet.com 80 If you respond to the question “what is apathy?” by saying “I don’t know and I don’t care”, you’ve got the correct answer. But if you didn’t get this joke, you may be suffering from impaired humour appreciation, according to research presented at this year’s Rotman Research Institute Conference (Toronto, ON, Canada; March 25...

Apathy is considered to be a core feature of Parkinson's disease (PD) and has been associated with a variety of states and symptoms of the disease, such as increased severity of motor symptoms, impaired cognition, executive dysfunction and dementia. Apart from the high prevalence of apathy in PD, which is estimated to be about 40%, the underlying pathophysiology remains poorly understood and cu...

Apathy is a quantitative reduction in goal-directed behaviors, having three subtypes. Despite executive deterioration in healthy aging, researchers have not investigated the "cognitive-deficit" subtype of apathy in healthy populations, which would result from executive dysfunction. We hypothesized that a relationship between apathy and executive function (EF) would be found in healthy older adu...

BACKGROUND Apathy is a disturbance of motivation, frequent in survivors of stroke. Several studies have evaluated the rate of apathy secondary to stroke and risk factors. Different conclusions and contradictory findings have been published. We aimed to perform a systematic review and meta-analysis of all studies evaluating apathy secondary to stroke to better estimate its rate and risk factors,...