General artificial intelligence counteracts the inductive bias of an algorithm and tunes for out-of-distribution generalization. A conspicuous impact is unceasing trend in improving deep learning performance. Although a quintessential attention-based object detection technique, DETR, shows better accuracy than its predecessors, deteriorates detecting small-sized (in-perspective) objects. This s...

Introduction: The most convincing argument for the role of hepatitis C virus (HCV) in pathogenesis some indolent non-Hodgkin lymphoma (iNHL) subtypes, especially marginal-zone lymphomas (MZL), is represented by retrospective observations tumor regression after viral eradication interferon (IFN)-free direct-acting antivirals (DAAs). However, no prospective studies this setting have been performe...

Embryonic cuttlefish can first respond to a variety of sensory stimuli during early development in the egg capsule. To examine the neural basis of this ability, we investigated the emergence of sensory structures within the developing epidermis. We show that the skin facing the outer environment (not the skin lining the mantle cavity, for example) is derived from embryonic domains expressing th...

There are reports of pretransplant sofosbuvir (SOF) plus ribavirin being effective in preventing recurrent hepatitis C virus (HCV) infection after liver transplantation (LT). The aim of this study was to assess the cost-effectiveness of this strategy in the area served by the North Italy Transplant program. We retrospectively assessed the impact of HCV infection on post-LT survival in 2376 cons...

BACKGROUND & AIM We performed lipid analyses at the early period of therapy in patients with chronic hepatitis C who underwent interferon (IFN)-free direct-acting antiviral (DAA) treatment, and we attempted to identify the factors that contributed to a rapid increase in the patients' serum low-density lipoprotein cholesterol (LDL-C) concentration. METHODS We retrospectively analyzed the cases...

Real-life data on interferon (IFN)-free direct acting antiviral (DAA) therapies for chronic hepatitis C (CHC) is limited for Asian Americans.To evaluate sustained virologic response (SVR) and adverse events (AE) in Asian Americans treated with sofosbuvir (SOF)-based, IFN-free DAA therapies.This is a retrospective study of 110 consecutive Asian Americans with HCV genotypes 1 to 3 or 6 treated wi...

UNLABELLED Elderly subjects have been historically underrepresented in clinical trials involving antiviral hepatitis C therapies. The aim of this analysis was to retrospectively evaluate the safety and efficacy of ledipasvir/sofosbuvir (LDV/SOF) by age groups of <65 years versus ≥65 years among subjects enrolled in phase 3 trials. Four open-label phase 3 clinical trials evaluated the safety and...

Using the notion of exponential QSR-dissipativity (i.e., dissipativity with respect to a quadratic supply rate given in terms real matrices Q, S,R), this article presents necessary and sufficient conditions for stabilizability nonlinear systems by linear static output feedback (SOF). It is shown that, under mild assumptions, stabilization closed-loop system around origin equivalent plant...

OBJECTIVES To validate two established frailty indexes and compare their ability to predict adverse outcomes in a diverse, elderly, community-dwelling sample of men and women. DESIGN Prospective observational study. SETTING A diverse defined geographic area of Boston. PARTICIPANTS Seven hundred sixty-five community-dwelling participants in the Maintenance of Balance, Independent Living, I...