Understanding the failure and damage mechanisms of soft biological tissue is critical to a sensitive and specific characterization of tissue injury tolerance and its relation to biological responses. Despite increasing experimental and analytical efforts, failure-related irreversible effects of soft biological tissue are still poorly understood. There is still no clear definition of what "damag...

Experimental and clinical studies demonstrate that early, controlled mobilization is superior to immobilization for primary treatment of acute musculoskeletal soft-tissue injuries and postoperative management. Optimal treatment and rehabilitation follow four steps that address response to trauma. First is treating the damaged area with PRICES: protection, rest, ice, compression, elevation, and ...

An epithelioid haemangioendothelioma developed at the site of injury sustained from an air gun pellet 20 years previously in an otherwise healthy 30 year old man, suggesting a possible traumatic aetiology in this case.

We report a case of a 20-year-old patient who sustained a mutilating crush injury to the left hand. After thorough debridement and stabilization of the skeletal injury, a radial forearm fascial free flap was used to resurface the distal soft tissue volar defect of two adjacent digits. This thin fascial flap allows for stable soft tissue coverage and provides a gliding surface for the exposed te...

Open clavicle fracture is an uncommon injury mostly caused by severe direct trauma. It is often associated with multiple organ injuries. Generally, surgical intervention with debridement and fracture repair is always indicated in order to prevent infection, non-union, and malalignment. In situations of bony exposure and significant contamination concomitant with severe soft tissue damage, the e...

REFERENCE: Bleakley C, McDonough S, MacAuley D. The use of ice in the treatment of acute soft-tissue injury: a systematic review of randomized controlled trials. Am J Sport Med. 2004; 32:251-261. CLINICAL QUESTION: What is the clinical evidence base for cryotherapy use? DATA SOURCES: Studies were identified by using a computer-based literature search on a total of 8 databases: MEDLINE, Proquest...

Most civilian nonfatal gunshot injuries and murders involve handguns. Gunshot wounds are often classified as being due to high-velocity or low-velocity projectiles, e.g. rifle or handgun rounds. However, this is a historical distinction, and there is overlap in energy that can be delivered to tissue by modern rifle and handgun rounds. Also, the same diameter (caliber) bullet can have different ...

spinal cord injury (sci)-induced systemic inflammatory response affects multiple organs outside the spi­nal cord. treatment options for such complications are lacking. valproic acid (vpa) is a histone deacetylase inhibitor, acting directly at the level of gene transcription by inhibiting histone deacetylation and making transcription sites more accessible. acetylation of histones is critical to...

COMPLEX, OPEN MAXILLOFACIAL FRACTURES ARE OFTEN ACCOMPANIED BY EXTENSIVE CONTAMINATION, CRUSH, OR AVULSION OF THE OVERLYING SOFT TISSUE, THERE HAVE BEEN TWO ALTERNATIVES TO TREATMENT: either radical debridement of all contaminated tissue, fixation of the underlying fractures, and soft tissue closure by pedicle flap or graft is done; or more conservative debridement is repeated multiple times un...