The objectives of this research were to determine total lipid content and corresponding fatty acid profiles in freshwater (n=10) marine fish (n=11) samples commonly consumed Bangladesh. Lipid was extracted by Solid Phase Dispersion method. Saponification esterification carried out the association official analytical chemists (AOAC) reference procedure with some simple modifications. acids analy...

Introduction of ?-N-methylated non-proteinogenic amino acids into peptides can improve their biological activities, membrane permeability and proteolytic stability. This is commonly achieved, in nature the lab, by assembling pre-methylated acids. The more appealing route methylating amide bonds challenging. Biology has evolved an ?-N-automethylating enzyme, OphMA, which acts on fused to its C-t...

Solid state fermentation is currently used in a range of applications including classical applications, such as enzyme or antibiotic production, recently developed products, such as bioactive compounds and organic acids, new trends regarding bioethanol and biodiesel as sources of alternative energy, and biosurfactant molecules with environmental purposes of valorising unexploited biomass. This ...

Rumen degradation kinetics and effective degradability of individual amino acids, total analysed amino acids (TAA) and crude protein (CP) of soybean meal were measured on four rumen-cannulated wethers using the nylon bag technique. Microbial contamination of the incubated residues was corrected using a continuous 15N intraruminal infusion and isolated solid associated bacteria as a reference sa...

This article reports the synthesis of a novel type of conjugate of three fundamental biological build blocks (i.e., saccharide, amino acids, and nucleobase) and their cell compatibility. The facile synthesis starts with the synthesis of nucleobase and saccharide derivatives, then uses solid-phase peptide synthesis (SPPS) to build the peptide segment (Phe-Arg-Gly-Asp or naphthAla-Phe-Arg-Gly-Asp...

Free fatty acids and monoglycerides have long been known to possess broad-spectrum antibacterial activity that is based on lytic behavior against bacterial cell membranes. Considering the growing challenges of drug-resistant bacteria and the need for new classes of antibiotics, the wide prevalence, affordable cost, and broad spectrum of fatty acids and monoglycerides make them attractive agents...

HBTU is a standard coupling agent commonly used for the activation of free carboxylic acids during the solution and solid phase peptide synthesis. 1-Hydroxybenzotriazole (HOBt) plays a significant role in reducing the racemization during peptide synthesis; hence it is regularly used as a coupling additive. Here, we are reporting the mild and facile conjugate addition of HOBt to E-vinylogous γ-a...

2-, 4-, 5-, and 6-hydroxynicotinic acids were crystallized in a pH-dependent manner using only water as the preferred solvent. The crystallization outcome was quite diverse: individual crystals of different sizes shapes, microcrystalline powders, crystalline aggregates, almost amorphous solids. Such variety solid forms demonstrates relevance pH control during processes.

DMB (Dimethylbarbituric) and DETB (Diethylthiobarbituric) are both barbituric thiobarbituric acid derivatives respectively, that forms enamines with the Nα amine of amino acids. These compounds were found to be stable crystalline solids show stability in standard acidic basic conditions used for solid-phase peptide synthesis (SPPS) strategies. protecting groups cleaved by a mild solution 2 % hy...