Airborne particulate matter (APM) is a major air pollutant, and the effect on human health of fine APM (PM2.5) deposited deep inside the lungs has recently become a serious concern. Moreover, soluble constituents may leach from APM, and intensify some health disorders. To identify the soluble chemical constituents of APM, size-classified APM was sampled in central Tokyo, and the elemental compo...

We have developed a microarray of cell culture environments composed of a combination of soluble factors and extracellular matrices for screening of cell culture environment.

in vitro lymphocyte responses of high responder (hr) and low responder (lr) guinea pigs from pe-ripheral blood lymphocytes (pbl) to parasite antigens soluble protein third stage larvae (spl3) and soluble protein adult stage ( spa), non-parasite antigen ovalbumin (ova) were examined. there was substantial differences between hr and lr guinea pigs in the rate of acquisition of responsiveness to t...

Imbalances in circulating angiogenic factors contribute to the pathogenesis of preeclampsia. To characterize levels of angiogenic factors in pregnant women with chronic hypertension, we prospectively followed 109 women and measured soluble fms-like tyrosine kinase 1 (sFlt1), soluble endoglin, and placental growth factor at 12, 20, 28, and 36 weeks' gestation and postpartum. Superimposed preecla...

The extracellular matrix (ECM) influences a variety of cellular functions, including survival, adhesion molecule expression, differentiation, and migration. The ECM composition of the epithelial basement membrane is altered in asthmatics. In this study, we elucidate the major survival signals received by bronchial epithelial cells in vitro by studying the effects of a variety of ECM factors and...

in order to study the yield and forage quality of intercropping barley (hordeum vulgare) and mustard (sinapis alba) in different planting dates, a factorial experiment based on randomized completely block design with three replications was carried out at farm research station, gonbad -e- qabus university. factors were included as three planting dates (15 november, 6 and 20 december 2006) and fo...

effects of seed priming by salicylic acid on some morpho-physiologic characteristics and yield of cowpea (vigna unguiculata l.) cultivar “parastou” was investigated under water deficit. experiment was conducted as a split block design with 3 replications in 2008-2009 at research farm of zanjan university. factors were including drought stress as a main factor in 2 levels (irrigation, water defi...

The severity of malaria is multi-factorial. It is associated with parasite-induced alteration in pro-inflammatory and anti-inflammatory cytokine and chemokine levels in host serum and cerebrospinal fluid. It is also associated with sequestration and cytoadherence of parasitized erythrocytes (pRBCs) in post-capillary venules and blood-brain barrier (BBB) dysfunction. The role of these factors in...

In patients with glioma, the tumor microenvironment can significantly impact pro-inflammatory immune cell functions. However, the mechanisms by which this occurs are poorly defined. Because immunosuppressive regulatory T cells (Treg) are over represented in the tumor microenvironment compared with peripheral blood, we hypothesized that the tumor may have an effect on Treg survival, migration, e...