نتایج جستجو برای: soluble fas ligand
تعداد نتایج: 201321 فیلتر نتایج به سال:
Article history: Received 25 July 2017 Received in revised form 17 November 2017 Accepted 23 November 2017 Available online 24 November 2017 Background:An increased rate of cell death by apoptosis has been implicated in both diabetes and atherosclerosis. Apoptosis can be induced through activation of the death receptors TNF receptor 1 (TNFR-1), TRAIL receptor 2 (TRAILR-2) and Fas. Soluble forms...
Fas ligand, best known as a death-inducer, is also a costimulatory molecule required for maximal proliferation of mature antigen-specific CD4+ and CD8+ T cells. We now extend the role of Fas ligand by showing that it can also influence thymocyte development. T cell maturation in some, but not all, strains of TCR transgenic mice is severely impaired in thymocytes expressing mutant Fas ligand inc...
In the manuscript entitled "Activation of the Fas/Fas ligand Pathway in Hypertensive Renal Disease in Dahl/Rapp Rats" Paul Sanders and Pei-Xuan Wang evaluated the renal lesions in hypertensive rats. They used immunohistochemistry to demonstrate an overexpression of Fas and Fas ligand in tubular epithelial and glomerular cells. They also used Western blotting to demonstrate activation of both ca...
BACKGROUND Human Fas ligand extracellular domain has been investigated as an important target protein in the field of medical biotechnology. In a recent study, the author developed an effective method to produce biologically active human Fas ligand extracellular domain derivatives using site-specific chemical modifications. FINDINGS A human Fas ligand extracellular domain derivative containin...
Apoptosis induced by Fas (CD95) ligation is frequently lost during tumor progression; however, there is no direct evidence to support an association of Fas loss-of-function with metastatic tumor behavior. To determine whether Fas loss-of-function is critical for acquisition of the metastatic phenotype, we have compared the ability of Fas-sensitive K1735 murine melanomas to form spontaneous lung...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید