نتایج جستجو برای: solution phase peptide synthesis

تعداد نتایج: 1546114  

Journal: :Chemical communications 2014
Mattan Hurevich Peter H Seeberger

Current strategies for the synthesis of glycopeptides require multiple manual synthetic steps. Here, we describe a synthesis concept that merges solid phase peptide and oligosaccharide syntheses and can be executed automatically using a single instrument.

Journal: :Chemical communications 2010
Karunakaran A Kalesh Lay Pheng Tan Kai Lu Liqian Gao Jigang Wang Shao Q Yao

Synthesis of a novel unnatural amino acid (2-FMPT) for the solid-phase synthesis of peptide-based probes suitable for target-specific activity-based profiling of protein tyrosine phosphatases from crude proteomes is reported.

2014
Dan Yuan Xuewen Du Junfeng Shi Ning Zhou Abdulgader Ahmed Baoum Bing Xu

This article reports the synthesis of a novel type of conjugate of three fundamental biological build blocks (i.e., saccharide, amino acids, and nucleobase) and their cell compatibility. The facile synthesis starts with the synthesis of nucleobase and saccharide derivatives, then uses solid-phase peptide synthesis (SPPS) to build the peptide segment (Phe-Arg-Gly-Asp or naphthAla-Phe-Arg-Gly-Asp...

Journal: :Chemosensors 2023

The in silico modelling of peptides complementary to lactoferrin was carried out using the Protein 3D software package and replication natural bonding site between pneumococcal surface protein (PSP) (LF). modeling based on analysis conjugated ion–hydrogen bond systems these proteins (CIHBS). oligopeptide EEVAPQAQAKIAELENQVHRLE proposed via computer synthesized solid phase synthesis technique, p...

Desmopressin acetate is a potent synthetic peptide hormone. A more acceptable route of Desmopressin acetate is a potent synthetic peptide hormone. That is administered via parenteral, intranasal, and oral routes. A more acceptable route of administration with potentially good bioavailability could be offered by transdermal delivery. The present work reports on the development of water-in-oil (w...

M. Gandomkar, M. Ghannadi Maragheh, M. Shamsaei, S.P. Shirmardi,

Background: Chlorotoxin is a 36-amino acid peptide found in the venom of the Leiurus quinquestriatus which blocks small-conductance chloride channels. Chlorotoxin binds preferentially to glioma cells that allow development of new methods for the treatment and diagnosis of several types of cancer. Thus chlorotoxin derivative was labeled with 131I for further investigation. Materials and...

Synthesis of a natural proline-rich cyclopolypeptide - rolloamide A [8] was carried out by coupling of tri- and tetrapeptide units Boc-Phe-Pro-Val-OMe and Boc-Pro-Leu-Pro-Ile-OMe after proper deprotection at carboxyl and amino terminals using carbodiimide chemistry in alkaline environment followed by cyclization of linear heptapeptide segment in the presence of base. The structure of synthesize...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1991
S Funakoshi H Fukuda N Fujii

The specific reaction between SH and iodoacetamide groups has been explored as the basis of an affinity-type purification procedure for peptides synthesized by the solid-phase technique. For this affinity-type purification procedure, we synthesized an SH precursor reagent bearing an acid-labile S-protecting group, pMB-SCH2CONHCH2CH2-SO2CH2CH2OCO2pNP (compound I), in which pMB is p-methoxybenzyl...

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