conclusions there was a significant association between pms scores and the prevalence of metabolic syndrome. further studies are needed to confirm and validate the relationships between lipid profile abnormalities and metabolic disorders with pms. objectives this study was designed to investigate the association of hormonal and metabolic factors with pms among iranian women of reproductive age....

severe overgrowth and tallness is very rare in human beings. the most common cause is gigantism due to the excessive secretion of the growth hormone, especially, before the closure of long bones’ epiphyseal growth plates. there are other rare disorders that are categorized on overgrowth syndromes. herein, we report an extremely rare, or even perhaps a unique, patient from iran. the clinical and...

W e report a Jordanian Arab family where two sibs developed the classical clinical and radiological features of pantothenate kinase associated neurode-generation (PKAN, formerly known as Hallervorden-Spatz disease) but in addition had an early onset cerebellar ataxia. 12 Using polymorphic microsatellite markers we have shown that this family is not linked to the pantothenate kinase gene (PA N K...

Recent experiments by Arnold et al. (Arnold, M.; Cavalcanti-Adam, E. A.; Glass, R.; Blummel, J.; Eck, W.; Kantlehner, M.; Kessler, H.; Spatz, J. P. ChemPhysChem 2004, 5, 383) revealed that a distance of less than 58-73 nm between receptor-ligand bonds is necessary to ensure focal adhesion in integrin-mediated cell adhesion on ligand-coated substrates. In this letter, we consider focal adhesion ...

In the wonderful frame of Cape Town, neuroscientists from all over the world met to discuss the role of metals in brain function. The day was opened by a very intriguing plenary lecture from James Connor (Penn State University). The topic of this comprehensive talk was the role of iron dyshomeostasis in neurological diseases. Dr. Connor illustrated how iron unbalance could be linked to a variet...

macrophage activating syndrome (mas) is a life-threatening disease seen in autoimmune diseases including lupus erythematosus, rheumatoid arthritis, still's disease, polyarteritis nodosa. it is characterized by fever, pancytopenia, liver failure, coagulopathy, and neurologic symptoms and high serum ferritin. a 27 yr. old female patient was admitted in shahid mostafa khomeini hospital (tehra...

primary immunodeficiencies (pid) are a group of disorders, characterized by an unusual susceptibility to infections. delay in diagnosis results in increased morbidity and mortality in affected patients. the purpose of this study was to determine the mortality rate of iranian immunodeficient patients referred to children medical center hospital affiliated to tehran university of medical sciences...