The two title compounds, di-mu-bromo-bis{[2,6-bis(pyrazol-1-yl-kappaN(2))pyridine-kappaN](perchlorato-kappaO)copper(II)}, [Cu(2)Br(2)(ClO(4))(2)(C(11)H(9)N(5))(2)], (I), and [2,6-bis(pyrazol-1-yl)pyridine]dibromocopper(II), [CuBr(2)(C(11)H(9)N(5))], (II), were synthesized by only slight modifications of the same reaction; compound (II) was formed by adding one molar equivalent of pyrazole (C(3)...

Monoclonal antibodies (mAbs) have proven to be useful for development of new therapeutic drugs and diagnostic techniques. To overcome the difficulties posed by their complex structure and folding, reduce undesired immunogenicity, and improve pharmacokinetic properties, a plethora of different Ab fragments have been developed. These include recombinant Fab and Fv segments that can display improv...

OCA-B (alternately called Bob1 and OBF-1) is a B cell-specific coactivator that interacts with the ubiquitously expressed Oct-1 and the B cell-restricted Oct-2 to activate transcription via the octamer site (5'-ATGCAAAT-3'). OCA-B-/- mice appear to undergo normal Ag-independent B cell maturation. However, Ag-dependent B cell differentiation, including germinal center formation, production of se...

I n this issue of the European Respiratory Journal, RIJSSENBEEKNOUWENS et al. [1] demonstrated that the benefit of a stay at high altitude was comparable in allergic and nonallergic adult asthmatic patients (allergy was defined on the basis of specific immunoglobulin (Ig)E to a panel of common aeroallergens). This benefit was substantial, exemplified by a discontinuation in oral steroids intake...

Synthesis and secretion of Ig by chicken lymphoid cells was studied. Both spleen and bursa cells synthesize and secrete IgM and IgG whereas Ig was not detected in thymus cells. In contrast to the spleen cells which synthesize H and L chains in balanced quantities, the bursa cells synthesize and secrete free L chains. In addition to the lymphoid cells which secrete IgM or IgG, the bursa appears ...

HGPRTase-deficient EBV-transformed B cell lines were shown to be effective fusion partners with mitogen-activated human B cells for the construction of Ig-producing human B cell hybridomas. In a series of experiments using these lines and B cells from several tissue sources, approximatley 20% of the cultures plated were consistently positive for growth after hypoxanthine-aminopterin-thymidine s...

We attempted an oral rush desensitization with mixed cow and sheep milk in a 6-year-old boy who had had adverse reactions to cow and goat milks. Skin prick tests and specific immunoglobulin (Ig) E to cow, sheep and goat milks were positive. The double-blind, placebo-controlled food challenge with cow milk was positive too. He underwent a 12-day sublingual-oral desensitization treatment with mix...

BACKGROUND Interleukin-1 (IL-1) is a powerful and important cytokine in myocarditis. The purpose of this study was to evaluate the effect and possible mechanism of hydrodynamics-based delivery of the IL-1 receptor antagonist (IL-1RA)-immunoglobulin (Ig) gene for treatment of rat experimental autoimmune myocarditis (EAM). METHODS AND RESULTS On the day after immunization, rats were transfected...

Among bone-marrow-derived (B) lymphocytes exist subpopulations of cells that can be induced to express the markers: surface immunoglobulin (Ig), the antigen associated with the immune response gene (Ia), and the receptor for the third complement component (CR). Inducible cells for the first two markers are found in bone marrow, and inducible cells for all three are in spleen. Experiments were d...

T h e T cell receptor for antigen is similar to that o f B cells (Ig) in that there are a very large number o f specificities and this reper to i re of specificities is clonally distributed. What appears unique about T cell recognit ion is the ability o f T cells to recognize foreign ant igen only in association with a p roduc t of the MHC (1, 2), whereas antibodies, in most cases, require only...