The detection of cancer at its earliest stage is crucial in order to increase the probability of a successful treatment. Optical techniques, specifically diffuse reflectance and fluorescence, may considerably improve the ability to detect pre-cancerous lesions. These techniques have high sensitivity to some biomarkers present on the tissues, providing morphological and biochemical information o...

Two new highly oxidized humulane sesquiterpenes, mitissimols D (1) and E (2) were isolated from the fruiting bodies of Lactarius mitissimus. Their structures were elucidated using extensive spectroscopic techniques including 1D and 2D NMR spectra.

A combination of advanced synthetic and single molecule spectroscopic techniques allowed us to demonstrate that macrocycles, covalently bound to a conjugated polymer backbone, raise the effective chain persistence length by at least a factor of 5.

Some spectroscopic techniques based on near infrared djode lasers are discussed with special emphasis on molecular spectroscopy. The semiconductor lasers provide for not only cheap coherent light sources of high quality, but also for new possibilities in experimental physics.

Euphorbia wallichii of the family Euphorbiaceae yielded a new rearranged pentacyclic triterpene of the multiflorane class which we have named spirowallichiione. The structure of this natural spirocompound was elucidated with the aid of modern spectroscopic techniques, including 2D-NMR.

Two new dibenzocyclooctadiene lignans, neglschisandrins C-D (1-2), were isolated from the stems of Schisandra neglecta. Their structures and stereochemistries were elucidated by spectroscopic methods, including 1D- and 2D-NMR and HR-ESI-MS techniques.

From the flowers of Baccharis medullosa DC (Asteraceae) two new ent-labdane-type diterpene glycosides were isolated. Structures were established by application of various spectroscopic techniques. The sugar residues were identified after acid hydrolysis of the isolated products.

Current density imaging (CDI) is a magnetic resonance (MR) imaging technique that could be used to study current pathways inside the tissue. The current distribution is measured indirectly as phase changes. The inherent noise in the MR imaging technique degrades the accuracy of phase measurements leading to imprecise current variations. The outcome can be affected significantly, especially at a...

Magnetic resonance imaging (MRI) and magnetic particle imaging (MPI) are powerful methods in the early diagnosis of diseases. Both imaging techniques utilize magnetic nanoparticles that have high magnetic susceptibility, strong saturation magnetization, and no coercivity. FeraSpinTM R and its fractionated products have been studied for their imaging performances; however, a detailed magnetic ch...

BACKGROUND Risk prediction of rupture of intracranial aneurysms is poor and is based mainly on lumen characteristics. However, characteristics of the aneurysm wall may be more informative predictors. The limited resolution of currently available imaging techniques and the thin aneurysm wall make imaging of wall thickness challenging. OBJECTIVE To introduce a novel protocol for imaging wall th...