Around the world, candidemia is becoming more common. In past thirty years, a number of factors, including AIDS epidemic, an increase in patients receiving immune-suppressive therapy for transplantation, and use antibiotics hospital settings even community, have changed epidemiology invasive fungal infections general particular. Usage broad-spectrum antibiotics, cancer treatment, Candida specie...

Active efflux is a widespread mechanism for bacterial resistance to antibiotics, which contributes to poor intrinsic susceptibility, cross-resistance to structurally diverse classes of drugs, or selection of other mechanisms of resistance. Thus, inhibition of efflux pumps appears to be (i) a promising strategy for restoring the activity of existing antibiotics, and (ii) a useful method to detec...

managing severe acute cholangitis because of its high mortality , which is reported to be up to 10%. The management of severe acute cholangitis is comprised of two key steps: first, rapid drainage of the obstructed bile duct; and second, administration of systemic antibiotics. To control systemic infection caused by acute cholangitis, systemic antibiotics via intravenous route should be initiat...

Background: There is much controversy about the ideal approach to the management of community acquired pneumonia (CAP). Recommendations differ from a pathogen directed approach to an empirical strategy with broad spectrum antibiotics. Methods: In a prospective randomised open study performed between 1998 and 2000, a pathogen directed treatment (PDT) approach was compared with an empirical broad...

Abstract: Active efflux is a wide-spread mechanism for bacterial resistance to antibiotics, which contributes to poor intrinsic susceptibility, cross-resistance to structurally diverse classes of drugs, or selection of other mechanisms of resistance. Thus, inhibition of efflux pumps appears to be (i) a promising strategy for restoring the activity of existing antibiotics, and (ii) a useful meth...

The rise of resistant pathogens and chronic infections tolerant to antibiotics presents an unmet need for novel antimicrobial compounds. Identifying broad-spectrum leads is challenging due to the effective penetration barrier of Gram-negative bacteria, formed by an outer membrane restricting amphipathic compounds, and multidrug resistance (MDR) pumps. In chronic infections, pathogens are shield...

Background & Aims: Based on serological studies the prevalence of Helicobacter Pylori infection in Iranian adults is up to 80%. Gastritis, peptic ulcer and gastric adenocarcinoma are common clinical outcomes of this infection in Iran. Since antibiotic resistance patterns of Helicobacter pylori are different geographically, local studies are highly required. Method: From April to December 2009, ...