Spinal intrathecal injections of the nonsteroidal antiinflammatory analgesics (NSAIAs) indomethacin and acetylsalicylic acid, which inhibit prostaglandin synthesis, cause dose-dependent hypoalgesia in the rat. Intrathecal injections of prostaglandin-E2 (PGE2) produce dose-dependent hyperalgesia. To determine whether this action of prostaglandins on the central nervous system is mediated through...

I N the ordinary type of spinal analgesia, whether induced by hypo, hyper, or isobaric solution, the result is a complete paralysis of all sensory and motor nerves from the toes right up to the segment desired. Hence in an abdominal operation, besides the abdominal area all the lumbar and sacral nerves get paralysed. It seems sometimes unnecessary that all the lumbar and sacral nerves be involv...

Patients with cholestatic disease exhibit pruritus and analgesia, but the mechanisms underlying these symptoms are unknown. We report that bile acids, which are elevated in the circulation and tissues during cholestasis, cause itch and analgesia by activating the GPCR TGR5. TGR5 was detected in peptidergic neurons of mouse dorsal root ganglia and spinal cord that transmit itch and pain, and in ...

Patients with pain after operation received morphine hydrochloride intrathecally in doses of 0.02 mg kg-1 (n = 30) and 0.2 mg kg-1 (n = 30). The high-dose group showed slightly longer-lasting and more potent analgesia than the low-dose group. Sedation, decreases in heart rate and systolic arterial pressure, oliguria, nausea and urinary retention were more frequent in the high-dose group. Two pa...

The involvement of respiratory system occurs mainly as a result of a high spinal block. Our case describes the unusual effect of mid-spinal analgesia. We encountered bronchospasm in an otherwise healthy patient undergoing inguinal hernia repair under subarachnoid block. The highest level of block was T6. The anxiety of the patient further aggravated the symptoms. This is probably the first repo...