Spinal fusion historically has been used extensively, and, recently, the lateral transpsoas approach to the thoracic and lumbar spine has become an increasingly common method to achieve fusion. Recent literature on this approach has elucidated its advantage over more traditional anterior and posterior approaches, which include a smaller tissue dissection, potentially lower blood loss, no need f...

BACKGROUND AND PURPOSE Various new delivery systems for recombinant human bone morphogenetic protein-2 (rhBMP-2) have been introduced to improve its efficacy in osteogenesis. Of these, we have previously developed heparin-conjugated PLGA nanospheres (HCPN) as a long-term delivery system for BMP-2. In vitro studies have shown that the BMP-2 long-term delivery system enhances the level of bone fo...

PURPOSE Spinal deformity in neurofibromatosis, when associated with dystrophic change, is a major treatment challenge. Early anterior and posterior spinal fusion is the accepted treatment plan for severe progressive kyphoscoliosis. Resection of the vertebral body as an additional step in correction and fusion has not been previously investigated. Information on the functional status of the neur...

INTRODUCTION: Demineralized bone matrix derived from human tissues has demonstrated the ability to aid in the stimulation of an osteoinductive response allowing for improved bone growth and fusion. In an effort to augment the available grafting material as well as increase fusion rates, the utilization of a demineralized bone matrix (DBM) as a graft extender or even as a graft substitute has be...

In this issue, we explore the role of biologics in spinal fusion. The treatment disorders has been revolutionized over last 25 years with introduction to enhance bone density preparation for surgery and promote bony arthrodesis fusion surgery. use these products become even more important era minimally invasive surgery, where graft surface area is at a premium.Use osteobiologics known migration...

OBJECTIVES We performed a systematic review of the literature to determine the safety and efficacy of bone morphogenetic protein (BMP) compared with bone graft when used specifically for revision spinal fusion surgery secondary to pseudarthrosis. METHODS The MEDLINE, EMBASE and Cochrane Library databases were searched using defined search terms. The primary outcome measure was spinal fusion, ...

Adjacent segment disease (ASD) is defined as degeneration that develops at mobile segments above or below a fused spinal segment and usually develops after spinal fusion or other back surgeries. Nearly 5 decades ago, the medical findings related to ASD were usually released in case reports as a relatively unusual complication of lumbar or lumbosacral fusions. Since the initial reports, ASD has ...

During the years from 1948 to 1956 a lumbo-sacral inter-body spinal fusion was done on forty-eight patients through a posterior approach. The operations have been divided chronologically into three groups. Improvements in the surgical technique were added in the two later groups, so that ultimately a new operative procedure was evolved and used in the last group, which gave the highest rate of ...

The incidence of failure in spinal fusion is still too high (Barr 1951). It has been stated that if the operation could be undertaken with little or no danger from shock, subsequent thrombosis and embolism, and if it would offer a high prospect of firm union with a short period of bed rest, then a larger proportion of patients would be grafted (Young 1953). Spinal fusion was the subject of an e...

Introduction. The use of locking plate technology for anterior lumbar spinal fusion has increased stability of the vertebral fusion mass over traditional nonconstrained screw and plate systems. This case report outlines a complication due to the use of this construct. Case. A patient with a history of L2 corpectomy and anterior spinal fusion presented with discitis at the L4/5 level and underwe...