Healthy pregnancy depends on proper placentation-including proliferation, differentiation, and invasion of trophoblast cells-which, if impaired, causes placental ischemia resulting in intrauterine growth restriction and preeclampsia. Mechanisms regulating trophoblast invasion, however, are unknown. We report that reduction of Inverted formin 2 (INF2) alters intracellular trafficking and signifi...

BACKGROUND AND PURPOSE Periprocedural embolization of debris during carotid stenting interventions may result in neurological deficit. This study was designed to evaluate in-hospital and 30-day adverse events in patients percutaneously treated for carotid artery disease with embolic protection devices. METHODS From 1999 to June 2002, a total of 442 consecutive patients underwent percutaneous ...

STUDY QUESTION What is the nature of cellular Corin expression in human gestational tissues? SUMMARY ANSWER CORIN is expressed in non-pregnant late secretory phase endometrium, first trimester human implantation sites and is up-regulated with decidualization ex vivo. WHAT IS KNOWN ALREADY Adequate trophoblast invasion and spiral artery remodeling/transformation is critical for successful im...

conclusions in most cases, the conus artery can be visualized in cardiac ct. a description of the conus artery should be a part of the standard clinical coronary ct angiography description. objectives to examine whether it is possible to visualize the conus artery in multi-slice computed tomography (ct). patients and methods in 79 consecutive patients (aged 56 ± 12.9 years; 13 women), 64-slice ...

in this study, generation of the transient evoked ooacoustic emissions in human ear has been simulated using a new electroacoustic model. the method of state variables was adopted to calculate the auditory model, and numerical integration methods have been used to solve differential equations in matlab. simulation results have been compared with the real data. in this study, latency curves, fre...

Introduction: Using computed tomography (CT) is increasing significantly in Iran and worldwide. Reduction of CT's radiation dose is a critical concern. The aim of this study was evaluating the effect of localizer kVp on spiral CT images when the tube current modulation (TCM) is activated. Materials and Methods: A special wedding cake phantom with circular in...

The ANP knockout mouse is reported to exhibit pregnancy-associated hypertension, proteinuria and impaired placental trophoblast invasion and spiral artery remodeling, key features of pre-eclampsia (PE). We hypothesized that these mice may provide a relevant model of human PE with associated fetal growth restriction (FGR). Here, we investigated pregnancies of ANP wild type (ANP(+/+)), heterozygo...

• Gadolinium-enhanced magnetic resonance angiography (MRA) is highly sensitive in detecting atherosclerotic renal artery stenosis (RAS) and is significantly more accurate in excluding the disease. Gadolinium-based imaging should be avoided in patients with glomerular filtration <30 mL/min per 1.73 m because of the risk of nephrogenic systemic fibrosis. • Spiral computed tomography angiography (...

Background Adenosine stress CMR perfusion imaging has numerous advantages over competing modalities for assessing CAD demonstrating high diagnostic and prognostic utility. However, adenosine stress CMR perfusion imaging is limited by motion-induced dark-rim artifacts (DRA) which may be mistaken for true perfusion abnormalities. We have previously demonstrated that a high-resolution variable-den...

BACKGROUND Although trials of image fusion, such as positron emission computed tomography and multislice spiral computed tomography (MSCT), have already demonstrated clinical usefulness, fusion of the coronary artery image and functional image by MSCT alone has not been reported yet. Here, a new idea of data analysis is proposed in which both regional cardiac function and the responsible corona...